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The safety information and warnings for alogliptin (Nesina) are crucial for ensuring the well-being of patients using this medication. Below are important details that should be carefully considered. If you have any concerns, please consult your healthcare provider.

• Heart Failure Risk: If you have recently experienced an acute coronary syndrome (ACS), such as a heart attack, notify your healthcare provider. Alogliptin may increase the risk of heart failure, especially within six months following an ACS. Symptoms to watch for include difficulty breathing during normal activities, fatigue, and swelling in the legs, ankles, or feet. Contact your provider immediately if these occur; hospitalization and discontinuation of alogliptin may be necessary. Increased risk is associated with a history of heart failure, kidney issues, or recent ACS.

• Severe Joint Pain: Some individuals have reported experiencing severe joint pain shortly after beginning treatment with DPP-4 inhibitors like alogliptin. These symptoms typically resolve upon discontinuation of the medication. If severe joint pain develops, discuss this with your provider to determine whether to continue the medication.

• Pancreatitis: There have been rare cases of pancreas inflammation (pancreatitis) in patients taking alogliptin. Symptoms include upper stomach pain, fever, nausea, and vomiting. Immediate medical attention is necessary if these symptoms appear, as discontinuation of alogliptin may be advised.

• Liver Problems: Though rare, some users of alogliptin have experienced liver damage, occasionally leading to fatal outcomes. If you notice symptoms such as yellowing of the skin, fatigue, dark urine, or pain in the upper right side of the abdomen, contact your healthcare provider. Liver function tests may be required to determine the cause, and stopping alogliptin could be necessary.

• Severe Itchy Rash: In rare cases, an itchy, blistering rash known as pemphigoid may occur, due to an immune response. If you develop such a rash, it is important to contact your healthcare provider. They may recommend stopping alogliptin and treating the rash with medications to reduce inflammation.

No specific contraindications have been identified for alogliptin (Nesina). Ensure to keep open communication with your healthcare provider and report any unusual symptoms promptly.

Common side effects:

• Upper respiratory tract infections
• Common colds
• Headaches
• Constipation
• Nausea
• Rash
• Diarrhea

Less common but important to monitor:

• Hypoglycemia (low blood sugar)
• High blood sugar

Serious side effects:

• Pancreatitis
• Inflammation of the pancreas
• Severe allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Balofloxacin
• Besifloxacin
• Chloroquine
• Ciprofloxacin
• Enoxacin
• Fleroxacin
• Flumequine
• Gatifloxacin
• Gemifloxacin
• Hydroxychloroquine
• Lanreotide
• Levofloxacin
• Lomefloxacin
• Moxifloxacin
• Nadifloxacin
• Norfloxacin
• Octreotide
• Ofloxacin
• Pasireotide
• Pazufloxacin
• Pefloxacin
• Prulifloxacin
• Rufloxacin
• Sparfloxacin
• Thioctic Acid
• Tosufloxacin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acebutolol
• Atenolol
• Betaxolol
• Bisoprolol
• Carteolol
• Carvedilol
• Celiprolol
• Esmolol
• Labetalol
• Levobunolol
• Metipranolol
• Metoprolol
• Nadolol
• Nebivolol
• Oxprenolol
• Penbutolol
• Pindolol
• Practolol
• Propranolol
• Sotalol
• Timolol