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The following safety information highlights important risks and precautions associated with using this medication. It is crucial to review these details carefully and discuss any concerns with your healthcare provider.

• Infection Risk from Shared Injection Supplies: Do not share Humulin 70/30 pens, syringes, or needles with others. Sharing can increase the risk of transmitting serious infections.

• Blood Sugar Variability with Insulin Changes: Altering your insulin regimen, such as switching brands or injection sites, can impact how your body responds, potentially leading to high or low blood sugar levels. Avoid injecting into areas with lipodystrophy, as this can also result in elevated blood sugar.

• Hypoglycemia Risk: Humulin 70/30 may cause dangerously low blood sugar levels. Regularly monitor your blood sugar to ensure it remains within a safe range, especially if you change your diet, exercise routine, consume alcohol, or take other diabetes medications. Individuals with liver or kidney issues should be particularly cautious.

• Low Potassium Levels: This medication can decrease blood potassium levels, posing a risk if you are also taking potassium-lowering medications, such as certain diuretics. Your healthcare provider may monitor your potassium levels and provide treatment to maintain them. Report symptoms like weakness, muscle cramps, nausea, vomiting, or irregular heartbeats.

• Fluid Retention and Heart Failure Risk with Glitazones: Using insulin, including Humulin 70/30, with medications like glitazones (e.g., pioglitazone) can lead to fluid retention, potentially causing or worsening heart failure. Be alert for signs such as sudden weight gain, swelling, difficulty breathing, and fatigue, and inform your healthcare provider if these occur.

Additionally, this medication should not be used during episodes of hypoglycemia. If any of these conditions apply to you, consult your healthcare provider before using this medication.

Common side effects:

• Low blood sugar
• Reactions at the injection site

Less common but important to monitor:

• Fat deposits or pitting under the skin
• Weight gain
• Swelling in areas like the legs, ankles, or feet

Serious side effects:

• Severely low blood sugar
• Dangerously low potassium levels
• Severe allergic reaction

When using Humulin 70/30 KwikPen, it's important to be aware of potential interactions with other substances that can affect your blood sugar levels. Certain medications and lifestyle factors may either increase or decrease the effectiveness of your insulin, leading to hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar).

Medications That May Increase the Risk of Hypoglycemia:

Some drugs can enhance the blood sugar-lowering effect of Humulin 70/30, increasing the risk of hypoglycemia. These include:

• Antidiabetic agents
• Salicylates (such as Aspirin)
• Sulfonamide antibiotics
• Monoamine oxidase inhibitors (MAOIs)
• Fluoxetine
• Disopyramide
• Fibrates
• Pentoxifylline
• ACE inhibitors
• Angiotensin II receptor blockers (ARBs)
• Somatostatin analogs (e.g., Octreotide)

If you're taking any of these medications alongside Humulin 70/30, your healthcare provider may need to adjust your insulin dose and recommend more frequent blood glucose monitoring.

Medications That May Decrease the Effectiveness of Humulin 70/30:

Other substances can reduce the blood sugar-lowering effect of Humulin 70/30, potentially leading to hyperglycemia. These include:

• Corticosteroids
• Isoniazid
• Niacin
• Estrogens and oral contraceptives
• Phenothiazines
• Danazol
• Diuretics
• Sympathomimetic agents (e.g., Epinephrine, Albuterol, Terbutaline)
• Somatropin
• Atypical antipsychotics
• Glucagon
• Protease inhibitors
• Thyroid hormones

In such cases, dose adjustments and increased frequency of blood glucose monitoring may be necessary.

Substances with Variable Effects on Blood Sugar:

Certain substances can either increase or decrease the blood sugar-lowering effect of Humulin 70/30, making blood sugar levels less predictable. These include:

• Beta-blockers
• Clonidine
• Lithium salts
• Alcohol

Pentamidine, a medication used to treat certain infections, may cause hypoglycemia followed by hyperglycemia. If you're using any of these substances, your healthcare provider may recommend closer monitoring of your blood glucose levels and possible dose adjustments.

Medications That May Mask Hypoglycemia Symptoms:

Some drugs can mask the typical signs and symptoms of hypoglycemia, making it harder to recognize low blood sugar episodes. These include:

• Beta-blockers
• Clonidine
• Guanethidine
• Reserpine

If you're taking any of these medications, it's crucial to monitor your blood sugar levels regularly and be aware of less obvious signs of hypoglycemia.

Lifestyle Factors:

Alcohol consumption can increase the risk of hypoglycemia. It's advisable to avoid or limit alcohol intake while using Humulin 70/30. Additionally, smoking tobacco may affect insulin effectiveness and blood sugar control. If you smoke, discuss this with your healthcare provider, as you may require closer monitoring and potential adjustments to your treatment plan.

Always inform your healthcare provider about all medications, supplements, and lifestyle habits to ensure safe and effective use of Humulin 70/30 KwikPen.