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The safety and warning information below is essential for the safe use of Xolegel (ketoconazole). Please read it thoroughly and consult your healthcare provider if you have any questions or concerns.

• Flammable Nature: Xolegel (ketoconazole) contains ingredients that are flammable. It is important to avoid contact with any flames or heat sources and refrain from smoking during and immediately after using this medication. Ensure that the Xolegel (ketoconazole) packaging is kept away from fires, flames, and any heat sources. Even when empty, do not dispose of the container in a fire.

• Skin Irritation: Application of Xolegel (ketoconazole) may cause skin irritation. If you experience irritation at the application site or if your dermatitis symptoms worsen, it is crucial to consult with your healthcare provider. Do not discontinue use of the medication without professional advice.

There are no known contraindications for Xolegel (ketoconazole) at this time. Always use this medication as directed by your healthcare provider to ensure safety and effectiveness.

Xolegel is a topical antifungal medication used to treat seborrheic dermatitis. When applied to the skin, it is generally not absorbed into the bloodstream in significant amounts, which minimizes the risk of interactions with other medications. Therefore, Xolegel is unlikely to interact with other drugs you may be taking.

However, it's important to be aware of certain precautions:

• Alcohol Consumption: While using Xolegel, avoid consuming alcohol. Although rare, some individuals have reported reactions similar to those experienced with Disulfiram (a medication used to treat chronic alcoholism) when combining alcohol with Ketoconazole, the active ingredient in Xolegel. Symptoms may include facial flushing, difficulty breathing, slight fever, and chest tightness. These reactions typically resolve on their own within 24 hours without lasting effects.

• Caffeine Intake: Ketoconazole can slow down the body's ability to process caffeine, potentially leading to increased effects such as nausea, nervousness, tremors, or difficulty sleeping. While this interaction is more commonly associated with oral forms of ketoconazole, it's advisable to monitor your caffeine intake and be alert to any unusual symptoms.

• Cannabis Use: Using cannabis while on ketoconazole treatment may alter the effects of cannabis, increasing the risk of adverse reactions. Symptoms to watch for include slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake. If you experience any of these, seek medical attention immediately.

• Grapefruit Consumption: Grapefruit and grapefruit juice can increase the levels of ketoconazole in your body, potentially leading to enhanced side effects. It's best to avoid grapefruit products during your treatment with Xolegel.

Always inform your healthcare provider about all medications, supplements, and herbal products you are currently using. This will help them provide personalized advice and ensure your treatment is both safe and effective.