This medication must not be used during pregnancy. It may harm an unborn baby. Your doctor should order a pregnancy test before starting this medication. Ask about reliable forms of birth control while using this medication and for 4 days after the last dose. If you are using this medication monthly, a pregnancy test should also be ordered before taking your monthly dose and birth control should be used during the 6-month treatment period and for 4 days after the last dose. If you become pregnant or think you may be pregnant, tell your doctor right away.

Nausea, stomach/abdominal pain, vomiting, dizziness, headache, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Other medications can affect the removal of ibrexafungerp from your body, which may affect how ibrexafungerp works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin), rifamycins (such as rifabutin, rifampin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin), among others.