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The safety information below outlines crucial warnings regarding the use of hydrocortisone (Anusol-HC). It is important for patients and healthcare providers to carefully consider these points to avoid potential risks and complications.

• Hormonal Issues and Withdrawal Symptoms: Long-term use of hydrocortisone (Anusol-HC) rectally may lead to adrenal suppression, a condition where your body reduces its natural production of steroid hormones. Abruptly stopping the medication can result in withdrawal symptoms such as dizziness, fatigue, and nausea. It is crucial to discuss with your healthcare provider before discontinuing use. They may recommend a rectal exam to ensure this medication is suitable for you. Risk factors include prolonged use, excessive dosage, covering the application area, and use in young children.

• Risk of Infections: Extended use of hydrocortisone (Anusol-HC) can increase the likelihood of developing new fungal or bacterial infections. If you currently have a skin infection, using this medication can exacerbate the problem. Signs of infection include redness, swelling, pain, pus, or a lack of improvement in symptoms after seven days. Consult your provider if you observe any of these signs.

• Skin Reactions: Prolonged or inappropriate use of hydrocortisone (Anusol-HC) may lead to skin issues such as thinning, stretch marks, visible veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rash. Your healthcare provider might suggest a rectal exam to verify the necessity of this treatment. Report any new or worsening skin conditions to your provider immediately.

Please adhere to the recommended guidelines and consult your healthcare provider for any concerns regarding hydrocortisone (Anusol-HC) use.

When using this medication, some individuals may experience mild side effects such as burning, itching, dryness, skin irritation, or changes in skin color around the rectal area. These effects are generally not serious, but if they persist or worsen, it is advisable to consult a healthcare provider. Additionally, some users may notice inflamed hair follicles, acne-like bumps, rash, thinning skin, stretch marks, or hair growth. These are typically not severe but should be monitored.

There are more serious side effects that, while rare, require immediate medical attention. These include new or persistent rectal bleeding, unusual bruising or bleeding, symptoms of stomach or intestinal bleeding like abdominal pain or black stools, and signs of infection such as a persistent sore throat or fever. Mental changes such as depression or mood swings, muscle weakness, irregular heartbeat, and bone pain are also serious.

In rare cases, the medication may be absorbed into the bloodstream, leading to symptoms like extreme tiredness, weight loss, headache, swelling of ankles or feet, increased thirst or urination, and vision problems. These are more likely in children or those using the medication long-term. A severe allergic reaction is also possible, with symptoms such as rash, severe dizziness, or trouble breathing. If any of these serious side effects occur, seek medical help immediately.