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You might experience some mild side effects such as burning, itching, dryness, or irritation of the skin and hair follicles, as well as changes in skin color around the rectal area. These effects are usually not serious and often resolve on their own. However, if they persist or worsen, it's important to consult a healthcare professional.

On rare occasions, more serious side effects could occur. Be vigilant for signs like new or persistent rectal bleeding, unusual bruising or bleeding, stomach pain, black or tarry stools, or vomit that resembles coffee grounds. Other serious symptoms may include bone pain, easily broken bones, mood changes, muscle weakness, irregular heartbeat, or signs of infection such as a persistent sore throat, fever, or pain during urination. If you notice any of these, seek medical advice immediately.

In rare cases, the medication could be absorbed into the bloodstream, leading to excessive corticosteroid effects. This is more common in children or those using the medication long-term. Watch for symptoms like extreme tiredness, unexplained weight loss, headaches, swelling of the ankles or feet, increased thirst or urination, and vision problems, and contact your healthcare provider if these occur.

Though extremely rare, a severe allergic reaction is possible. If you experience a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek emergency medical attention promptly. If you notice any side effects not mentioned here, reach out to your healthcare provider for further guidance.