Methotrexate Sodium Coupons & Discount Card - Compare Prices Near You

Methotrexate is a powerful medication that, in rare cases, can lead to severe or even life-threatening side effects. It is typically prescribed for cancer or significant autoimmune disorders such as psoriasis and rheumatoid arthritis. Below are critical safety and warning details you should be aware of:

• Usage Restrictions: Do not use methotrexate formulations with preservatives for high-dose treatments or spinal cord injections (intrathecal use).

• Pregnancy Warnings: Methotrexate can cause birth defects or fetal death. Women should avoid becoming pregnant while on this medication. It is contraindicated for pregnant women with psoriasis or rheumatoid arthritis.

• Monitoring Requirements: Individuals with kidney issues or fluid retention conditions like ascites or pleural effusion require careful monitoring. Dosage adjustments or discontinuation may be necessary.

• Drug Interactions: Using methotrexate, especially at high doses, with NSAIDs (e.g., indomethacin, ketoprofen) can lead to severe blood, bone marrow, and gastrointestinal issues. Avoid NSAIDs with high-dose methotrexate. Low-dose aspirin for heart attack or stroke prevention is permissible if advised by your doctor.

• Liver Health: Long-term methotrexate use can potentially harm the liver. Regular liver biopsies may be recommended for ongoing treatment.

• Rare Side Effects: Methotrexate might cause severe lung issues, skin reactions, diarrhea, or mouth sores. It can also rarely lead to tumor development, in which case, treatment should be halted and medical attention sought immediately.

• Tumor Lysis Syndrome: For cancer treatments, methotrexate may trigger tumor lysis syndrome due to rapid cancer cell breakdown. Staying hydrated and possibly taking additional medication is advised. Notify your doctor if you experience irregular heartbeat, back pain, kidney-related symptoms, or muscle issues.

• Radiation Therapy Interaction: Methotrexate combined with radiation therapy may increase the risk of tissue and bone damage. Discuss potential risks and benefits with your healthcare provider.

In case of an overdose or if severe side effects occur, seek immediate medical attention. Always consult your doctor or pharmacist for detailed information regarding safe methotrexate use.

You might experience nausea, vomiting, stomach pain, drowsiness, or dizziness while taking this medication. These are common side effects and usually mild, but should they persist or worsen, it's important to inform your healthcare provider. Temporary hair loss can also occur, but hair growth typically resumes once treatment concludes.

In some cases, more serious side effects may arise. Notify your healthcare provider immediately if you encounter mouth sores, diarrhea, signs of anemia like unusual tiredness or pale skin, or symptoms of liver problems such as persistent nausea or vomiting, dark urine, abdominal pain, or yellowing of the skin. Other concerning signs include easy bruising or bleeding, black stools, swollen glands, bone pain, unusual skin discoloration, signs of kidney issues like changes in urine output, dry cough, or muscle weakness.

Seek urgent medical attention for very serious side effects, such as irregular heartbeat, vision changes, weakness on one side of the body, severe headache, neck stiffness, mood changes, or seizures. The medication may weaken your immune system, increasing the risk of serious infections. Be vigilant for signs of infection such as a persistent sore throat, fever, chills, or cough, and report these immediately.

Though rare, serious allergic reactions can occur. If you notice symptoms such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing, obtain emergency medical help. If you experience any other unexpected effects, consult your healthcare provider for guidance.