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Methotrexate Sodium

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Methotrexate is used to treat certain types of cancer, severe psoriasis, or rheumatoid arthritis. It may also be used to treat a certain type of arthritis in children (polyarticular juvenile idiopathic arthritis - pJIA). Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and blocking the immune system from attacking healthy tissue. Early treatment of rheumatoid arthritis with methotrexate helps to reduce further joint damage and to preserve joint function.
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1GM, Methotrexate Sodium (30 Solution Reconstituteds)

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$2189.79

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Methotrexate Sodium savings card

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Warnings

Methotrexate has rarely caused serious (sometimes fatal) side effects. This medication should be used only to treat cancer or severe diseases caused by an overactive immune system (such as psoriasis, rheumatoid arthritis). Methotrexate has caused birth defects and death in unborn babies. Women must avoid becoming pregnant while taking this medication. Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. (See also Precautions section.) If you have kidney problems or excess body water (ascites, pleural effusion), you must be closely monitored and your dose may be adjusted or stopped by your doctor. Methotrexate (usually at high dosages) has rarely caused severe (sometimes fatal) blood/bone marrow problems (decreasing your body's ability to fight infections) and stomach/intestinal disease (such as bleeding) when used at the same time as non-steroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ketoprofen). NSAIDs should not be used with high-dose methotrexate. Caution is advised if you also take aspirin. NSAIDs/aspirin may be used with low-dose methotrexate such as for the treatment of rheumatoid arthritis if directed by your doctor. If your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details on the safe use of these drugs (such as close monitoring by your doctor, keeping the same doses of NSAIDs). In rare instances, this drug may also cause liver problems when it is used for long periods of time. If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis). () Lumps (tumors/abnormal growths) may very rarely appear during methotrexate use. The drug must be stopped and treatment may be needed. Tell your doctor right away if new lumps/growths occur. When used to treat tumors, methotrexate sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To lower your risk, drink plenty of fluids unless your doctor directs you otherwise. Also, your doctor may prescribe an additional medication. Tell your doctor right away if you have symptoms such as irregular heartbeat, low back/side pain, signs of kidney problems (such as pink/bloody urine, change in the amount of urine, painful urination), or muscle spasms/weakness. When this medication is used with radiation treatment, it may rarely increase the risk of tissue and bone damage. Discuss the risks and benefits of your treatment with your doctor.

Methotrexate Sodium Side Effects

Nausea, vomiting, stomach pain, drowsiness, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Temporary hair loss may occur. Normal hair growth should return after treatment has ended. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: mouth sores, diarrhea, signs of anemia (such as unusual tiredness, pale skin), signs of liver problems (such as nausea/vomiting that doesn't stop, dark urine, stomach/abdominal pain, yellowing eyes/skin), easy bruising/bleeding, black stools, enlarged glands/lymph nodes, bone pain, unusual pain and discoloration of the skin, signs of kidney problems (such as change in the amount of urine), dry cough, muscle weakness. Get medical help right away if you have any very serious side effects, including: weakness on one side of the body, neck stiffness, severe headache, vision changes, irregular heartbeat, mental/mood changes, seizures. This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug include: acitretin, asparaginase, chloramphenicol, leflunomide, other drugs that can cause kidney problems (such as cisplatin), other drugs that can cause liver problems (such as azathioprine, sulfasalazine, retinoids such as isotretinoin), penicillins, phenytoin, probenecid, procarbazine, pyrimethamine, sulfa medications, tetracyclines. Certain drugs that reduce stomach acid (proton pump inhibitors-PPIs such as esomeprazole, omeprazole, pantoprazole) may increase the amount of methotrexate in your blood. This effect may increase the risk of side effects, especially with high-dose methotrexate treatment. Ask your doctor or pharmacist for details and ways to lessen the risk of side effects.
Methotrexate Sodium FAQs
What does methotrexate sodium do?

Methotrexate sodium is a medication that interferes with the growth of certain cells in the body, particularly those that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. It is commonly used to treat certain types of cancer, severe psoriasis, and rheumatoid arthritis by slowing down the immune system and reducing inflammation.

Methotrexate is not commonly associated with causing low sodium levels, also known as hyponatremia. However, it can have various side effects, and individual responses to medication can vary. If there are concerns about sodium levels or any symptoms suggestive of hyponatremia, it is important to consult a healthcare provider for further evaluation and management.

Yes, methotrexate sodium is a chemotherapy drug. It is used to treat certain types of cancer by interfering with the growth of cancer cells. Additionally, it is used in lower doses to treat autoimmune diseases such as rheumatoid arthritis and psoriasis.

The major side effect of methotrexate is bone marrow suppression, which can lead to a decrease in blood cells, increasing the risk of infections, anemia, and bleeding. Other significant side effects include liver toxicity and gastrointestinal issues such as nausea and vomiting. Regular monitoring by a healthcare provider is essential to manage these risks.

When taking methotrexate, it is advisable to avoid foods that are high in folic acid, as methotrexate can interfere with folic acid metabolism. Foods rich in folic acid include leafy green vegetables, fortified cereals, and certain beans. Additionally, alcohol consumption should be limited or avoided, as it can increase the risk of liver damage when combined with methotrexate. It is always best to consult with a healthcare provider for personalized dietary recommendations while on methotrexate.

Methotrexate is commonly used to treat certain types of cancer, autoimmune diseases such as rheumatoid arthritis, and severe psoriasis. Its benefits include reducing inflammation, slowing disease progression, and alleviating symptoms associated with these conditions. It can help improve joint function and quality of life in patients with rheumatoid arthritis and control skin symptoms in psoriasis. In cancer treatment, it works by interfering with the growth of cancer cells.

Methotrexate can cause several side effects and potential damage to the body. It may affect the liver, leading to liver damage or elevated liver enzymes. It can also suppress bone marrow, resulting in decreased blood cell production, which may cause anemia, increased risk of infection, and bleeding issues. Methotrexate can affect the gastrointestinal tract, causing nausea, vomiting, and mouth sores. Additionally, it may cause lung damage, leading to pulmonary toxicity or pneumonitis. Regular monitoring by a healthcare provider is essential to manage these risks.

Yes, it is recommended to flush the toilet twice after using it when taking methotrexate. This precaution helps ensure that any residual medication in the urine is adequately diluted and reduces the risk of exposure to others.

Methotrexate can potentially affect electrolyte levels, although it is not a common side effect. It may cause imbalances such as low potassium or calcium levels in some cases. Regular monitoring of blood tests is recommended to check for any changes in electrolyte levels during methotrexate therapy.

Methotrexate can lead to deficiencies in folic acid, as it inhibits the enzyme dihydrofolate reductase, which is necessary for the conversion of folic acid to its active form. This can result in side effects such as mouth sores, gastrointestinal discomfort, and elevated liver enzymes. To mitigate these effects, folic acid supplementation is often recommended for patients taking methotrexate.

The most common complication of methotrexate is gastrointestinal upset, which can include symptoms such as nausea, vomiting, and abdominal discomfort. Additionally, methotrexate can cause liver toxicity, so regular monitoring of liver function tests is recommended. Bone marrow suppression is another potential complication, leading to decreased blood cell counts.

Yes, methotrexate is considered a type of chemotherapy. It is an antimetabolite that is used to treat certain types of cancer by interfering with the growth of cancer cells. Additionally, methotrexate is also used in lower doses to treat autoimmune diseases such as rheumatoid arthritis and psoriasis.

Methotrexate sodium is classified as an antimetabolite and antifolate drug. It is commonly used in the treatment of certain types of cancer, autoimmune diseases, and as a disease-modifying antirheumatic drug (DMARD) for conditions like rheumatoid arthritis.

When taking methotrexate, it is advisable to avoid foods that are high in folic acid, as methotrexate can interfere with folic acid metabolism. Foods rich in folic acid include leafy green vegetables, fortified cereals, and certain beans. Additionally, alcohol consumption should be limited or avoided, as it can increase the risk of liver damage when combined with methotrexate. It is important to follow any specific dietary recommendations provided by a healthcare provider.

Methotrexate is not classified as a chemotherapy drug for lupus. It is an immunosuppressant and disease-modifying antirheumatic drug (DMARD) that is sometimes used to treat lupus, particularly when there is joint involvement. It helps reduce inflammation and modulate the immune system.

While taking methotrexate, one should avoid consuming alcohol, as it can increase the risk of liver damage. Additionally, it is advisable to avoid nonsteroidal anti-inflammatory drugs (NSAIDs) unless specifically directed by a healthcare provider, as they can increase the risk of side effects. Patients should also avoid live vaccines, as methotrexate can weaken the immune system. It is important to discuss any other medications, supplements, or dietary changes with a healthcare provider to prevent potential interactions.

Yes, it is recommended to flush the toilet twice after using it when taking methotrexate. This precaution helps ensure that any residual medication in the urine is adequately diluted and reduces the risk of exposure to others.

Methotrexate can affect several organs in the body. It primarily impacts the liver, potentially causing liver damage or elevated liver enzymes. It can also affect the kidneys, leading to renal impairment. Additionally, methotrexate can impact the bone marrow, resulting in bone marrow suppression, which affects blood cell production. The gastrointestinal tract may also be affected, causing issues such as mucositis or gastrointestinal upset. Regular monitoring of these organs is important during methotrexate therapy.

Methotrexate can cause a range of side effects, and how it affects an individual can vary. Common side effects include nausea, fatigue, and mouth sores. Some people may experience more severe side effects such as liver damage, lung issues, or a drop in blood cell counts. It's important for individuals taking methotrexate to be closely monitored by their healthcare provider to manage any adverse effects and adjust the dosage if necessary.