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Methotrexate Sodium

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generic Trexall

Methotrexate is a medication primarily used in the treatment of various types of cancer, including leukemia, osteosarcoma, and head and neck cancer. It is also effective in managing non-cancer conditions such as severe psoriasis and rheumatoid arthritis. Additionally, it is used for treating polyarticular juvenile idiopathic arthritis in children. Methotrexate belongs to a group of drugs known as antimetabolites, which function by slowing down or halting the growth of cancer cells and preventing the immune system from attacking healthy tissues. This can help to reduce joint damage and preserve joint function in conditions like rheumatoid arthritis. Methotrexate is typically administered via injection, with low doses possibly given during a brief visit to a healthcare provider's office, while higher doses may require a hospital stay. Common side effects include low white blood cell count, mouth sores, and nervous system issues.
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1GM, Methotrexate Sodium (30 Solution Reconstituteds)

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CVS

$2174.46

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Walgreens

$593.30

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$1603.73

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$1826.69

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Methotrexate Sodium savings card

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$2174.46

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Methotrexate Sodium dosage forms

The average cost for 30 Solution Reconstituteds of Methotrexate Sodium (generic Trexall) at 1GM is $593.3 with a free coupon. This is 12.19% off the average retail price of $4868.35
DosageQuantityPrice fromPer unit
1GM30 Solution Reconstituteds$593.3$19.78

Methotrexate Sodium Warnings

Methotrexate is a medication that can potentially cause serious, sometimes fatal, side effects. It is typically prescribed for cancer or severe autoimmune conditions such as psoriasis and rheumatoid arthritis. Below are important safety considerations you need to be aware of when taking methotrexate:

  • Pregnancy Risks: Methotrexate can cause birth defects and miscarriage. Women must avoid becoming pregnant while on this medication, and it should not be used for non-cancer conditions during pregnancy.

  • Allergic Reactions: Some individuals may experience allergic reactions. Seek immediate medical attention if you experience symptoms such as itching, fever, nausea, difficulty breathing, or rapid heartbeat.

  • Preservative Concerns: Methotrexate formulations containing benzyl alcohol are harmful to newborns, individuals on high doses, or those receiving intrathecal injections. Consult your healthcare provider if you have concerns.

  • Blood Cell Counts: Methotrexate may lead to low blood cell counts, increasing the risk of fatigue, bleeding, and infections. Regular monitoring is essential.

  • Infection Risk: This medication can heighten the risk of infections, particularly opportunistic ones. Contact your healthcare provider if you experience fever, muscle aches, severe fatigue, cough, or breathing difficulties.

  • Kidney and Liver Damage: Methotrexate may cause kidney and liver damage. Individuals with pre-existing conditions or on high dosages should be closely monitored.

  • Nervous System Issues: High doses or intrathecal injections can cause severe nervous system problems, such as headaches, seizures, or vision changes.

  • Digestive Tract Damage: Possible side effects include vomiting, diarrhea, and stomach bleeding. Medical attention is necessary for sudden stomach pain or bloody stools.

  • Lung Problems: Methotrexate can cause serious lung issues such as interstitial lung disease. Report new or worsening respiratory symptoms immediately.

  • Skin Reactions: Serious skin reactions are possible, including Stevens-Johnson syndrome. Immediate medical attention is required for blisters or peeling skin.

  • Folic Acid Levels: Methotrexate affects folic acid levels, which is crucial for DNA synthesis. Folic acid supplements should not be taken without consulting your healthcare provider.

  • New Cancer Risks: There is a potential risk for developing new cancers, particularly affecting white blood cells.

  • Tumor Lysis Syndrome: This syndrome, associated with cancer treatment, can cause dangerous blood imbalances. Stay hydrated and monitor for symptoms like irregular heartbeat or kidney issues.

  • Fertility Concerns: Methotrexate may affect fertility, possibly causing irreversible changes. Discuss fertility preservation options with your provider if needed.

  • Radiation Therapy Risks: When used with radiation, methotrexate may increase risks of tissue and bone damage.

  • Fluid Retention: Methotrexate can accumulate in body fluid buildup, increasing the risk of side effects.

  • Dosing Errors: Methotrexate dosages vary greatly between cancer and non-cancer treatments. Proper dosing is crucial to minimize serious side effects.

Contraindications:

  • Do not use methotrexate if you have had severe allergic reactions to it or if you are pregnant and using it for non-cancer conditions.

Always consult with your healthcare provider for personalized advice and before making any changes to your medication regimen.

Methotrexate Sodium Side Effects

Common side effects:

  • nausea
  • vomiting
  • stomach pain
  • drowsiness
  • dizziness
  • temporary hair loss

Less common but important to monitor:

  • mouth sores
  • diarrhea
  • signs of anemia
  • persistent nausea or vomiting
  • dark urine
  • yellowing of the skin or eyes
  • easy bruising or bleeding
  • black stools
  • enlarged glands
  • bone pain
  • changes in urination
  • dry cough
  • muscle weakness

Serious side effects:

  • irregular heartbeat
  • vision changes
  • weakness on one side of the body
  • severe headache
  • neck stiffness
  • mental or mood changes
  • seizures
  • serious infections
  • rash
  • itching or swelling
  • severe dizziness
  • difficulty breathing

Methotrexate Sodium Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Zoster Vaccine, Live

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Methotrexate Sodium FAQs
What does methotrexate sodium do?

Methotrexate sodium is a medication that interferes with the growth of certain cells in the body, particularly those that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. It is commonly used to treat certain types of cancer, severe psoriasis, and rheumatoid arthritis by slowing down the immune system and reducing inflammation.

Yes, methotrexate sodium is a chemotherapy drug. It is used to treat certain types of cancer by interfering with the growth of cancer cells. Additionally, it is used in lower doses to treat autoimmune diseases such as rheumatoid arthritis and psoriasis.

The major side effect of methotrexate is bone marrow suppression, which can lead to a decrease in blood cells, increasing the risk of infections, anemia, and bleeding. Other significant side effects include liver toxicity and gastrointestinal issues such as nausea and vomiting. Regular monitoring by a healthcare provider is essential to manage these risks.

Methotrexate is not classified as a chemotherapy drug for lupus. It is an immunosuppressant and disease-modifying antirheumatic drug (DMARD) that is sometimes used to treat lupus, particularly when there is joint involvement. It helps reduce inflammation and modulate the immune system.

The most common complication of methotrexate is gastrointestinal upset, which can include symptoms such as nausea, vomiting, and abdominal discomfort. Additionally, methotrexate can cause liver toxicity, so regular monitoring of liver function tests is recommended. Bone marrow suppression is another potential complication, leading to decreased blood cell counts.