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The following safety information outlines critical warnings and contraindications associated with the use of this medication. Please read them thoroughly and discuss any concerns with your healthcare provider.

• Drug-Induced Lupus-Like Symptoms: Rarely, hydralazine can trigger symptoms similar to systemic lupus erythematosus (SLE), such as joint pain, facial rash, and fever. These symptoms typically resolve after discontinuing the drug, although the duration may vary. Notify your healthcare provider immediately if symptoms occur to consider alternative treatments.

• Blood Disorders: Some individuals may experience a reduction in red and white blood cells, leading to symptoms like dizziness, fatigue, and an increased risk of infections. Regular blood tests may be recommended by your healthcare provider to monitor cell counts before and during treatment.

• Nerve Effects: Hydralazine may cause numbness, tingling, or burning sensations in the hands or feet. If these occur, consult your healthcare provider, who may suggest vitamin B6 supplements to manage these symptoms.

• Cardiac Risks: This medication may not be suitable for individuals with a history of heart attacks, as it can potentially induce cardiac events. Additionally, hydralazine may exacerbate blood flow issues in those with heart valve problems or a history of stroke. Discuss your cardiovascular history with your provider before starting this medication.

• Contraindications: Do not use hydralazine if you have Coronary Artery Disease (CAD) or Mitral Valvular Rheumatic Heart Disease due to significant health risks.

If you have any of the conditions mentioned or experience any concerning symptoms, consult your healthcare provider promptly to ensure safe and effective use of this medication.

Common side effects:

• Headaches
• Nausea
• Vomiting
• Diarrhea
• Decrease in appetite

Less common but important to monitor:

• Constipation
• Low blood pressure
• Dizziness
• Tingling, burning, or numbness in the hands or feet
• Flushing
• Difficulty urinating
• Rashes
• Rapid or abnormal heartbeat
• Chest pain

Serious side effects:

• Heart attack

Hydralazine is a medication commonly prescribed to manage high blood pressure by relaxing blood vessels, allowing blood to flow more easily. However, it's important to be aware of potential interactions with other substances that can affect its effectiveness or increase the risk of side effects.

Interactions with Other Medications:

• Other Blood Pressure Medications: Combining hydralazine with other antihypertensive drugs can lead to an excessive drop in blood pressure.

• Monoamine Oxidase Inhibitors (MAOIs): Used to treat depression, MAOIs can intensify hydralazine's blood pressure-lowering effects, potentially causing dangerously low blood pressure.

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Medications like Ibuprofen and Aspirin may reduce hydralazine's effectiveness in lowering blood pressure.

• Beta Blockers: Drugs such as metoprolol and Propranolol can interact with hydralazine, leading to increased levels of both medications in the body and a higher risk of side effects.

• Muscle Relaxants: Medications like Tizanidine may cause an unsafe drop in blood pressure when taken with hydralazine.

Interactions with Supplements and Herbal Products:

• Vitamin B6 (Pyridoxine): Hydralazine can lead to a deficiency in vitamin B6, which may cause symptoms like numbness and tingling. Supplementing with vitamin B6 can help alleviate these side effects.

• Coenzyme Q10 (CoQ10): There is some evidence that hydralazine might impair the body's ability to produce CoQ10, suggesting that supplementation could be beneficial.

• Coleus Forskohlii: This herbal supplement may interact with hydralazine, potentially leading to unpredictable effects on blood pressure.

Alcohol Interaction:

• Consuming alcohol while taking hydralazine can enhance its blood pressure-lowering effects, increasing the risk of dizziness or fainting. It's advisable to limit or avoid alcohol during treatment.

Food Interaction:

• Taking hydralazine with food can increase the medication's levels in the blood, though this effect may not be clinically significant.

Important Considerations:

Always inform your healthcare provider about all medications, supplements, and herbal products you are currently using before starting hydralazine. This will help prevent potential interactions and ensure the medication works effectively and safely for you.