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The following guidelines offer crucial safety information regarding the use of topical hydrocortisone. Please read them carefully and discuss any concerns with your healthcare provider.

• Hormone Issues and Withdrawal: Long-term use of topical hydrocortisone, especially over extensive skin areas, may lead to adrenal suppression, a condition where the body reduces its production of natural steroid hormones. Abrupt discontinuation can cause withdrawal symptoms such as skin swelling, rash, and burning. To minimize the risk, your healthcare provider will prescribe the lowest effective dose for the shortest duration. If extended use is necessary, monitoring of adrenal function through lab tests may be required. Always consult your provider before stopping the medication. Risk factors include prolonged use, excessive application, and covering treated areas with a bandage, particularly in young children.

• Elevated Blood Sugar: Prolonged application of topical hydrocortisone on large skin areas may increase blood sugar levels, potentially leading to diabetes. Regular blood sugar monitoring is advised if you have diabetes. Report symptoms like increased thirst or frequent urination to your healthcare provider. Risks are heightened with long-term and excessive use.

• Infection Risks: Extended use of topical hydrocortisone can increase the likelihood of developing or worsening skin or mouth infections, including fungal or bacterial types. Avoid using it on infected areas as it may exacerbate the condition. If you experience redness, swelling, pain, pus, or if symptoms persist beyond seven days, contact your provider. These could indicate a new infection. Risk factors include use beyond seven days.

• Skin Reactions: Excessive or prolonged use of topical hydrocortisone heightens the risk of various skin issues, such as thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, skin color changes, or rash. Your provider will aim to use the lowest effective dose for the shortest time to avoid severe reactions. Promptly report any new or worsening skin issues to your healthcare provider. Risks are associated with misuse or overuse.

If you have any questions or require further clarification, please consult your healthcare provider to ensure safe and effective use of this medication.

Common side effects:

• Stinging
• Burning
• Itching
• Irritation
• Dryness
• Redness

Less common but important to monitor:

• Folliculitis
• Stretch marks
• Skin thinning
• Discoloration
• Acne-like bumps
• Unwanted hair growth
• Worsening skin infection

Serious side effects:

• Absorption into bloodstream leading to unusual tiredness
• Weight loss
• Headaches
• Swelling of the ankles or feet
• Increased thirst or urination
• Vision problems
• Serious allergic reaction

Hydrocortisone butyrate is a topical corticosteroid used to treat various skin conditions by reducing inflammation and itching. When applied to the skin, it is generally absorbed in minimal amounts, making systemic interactions uncommon. However, certain factors can increase absorption, such as applying the medication over large areas, using it for extended periods, or covering the treated area with occlusive dressings. In these situations, the medication may enter the bloodstream in higher amounts, potentially leading to interactions with other drugs.

One notable interaction involves medications that affect blood sugar levels. Hydrocortisone butyrate can elevate blood glucose, which may interfere with the effectiveness of antidiabetic drugs. If you have diabetes and are using hydrocortisone butyrate, it's important to monitor your blood sugar levels closely and consult your healthcare provider for appropriate adjustments to your diabetes management plan.

Additionally, hydrocortisone butyrate may interact with certain medications that influence the body's electrolyte balance, such as potassium-depleting agents. This can lead to imbalances that might require monitoring and management.

It's also advisable to avoid consuming alcohol while using hydrocortisone butyrate, as alcohol can exacerbate certain side effects of corticosteroids.

Always inform your healthcare provider about all medications, supplements, and over-the-counter products you are using to ensure safe and effective treatment.