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The safety and warning information provided here is essential for anyone considering the use of Invirase (saquinavir). It outlines potential risks, necessary precautions, and special instructions for specific populations. Please review carefully and discuss any concerns with your healthcare provider.

• Medication Interactions: Some drugs can interfere with the body's ability to clear Invirase (saquinavir), affecting its efficacy and increasing side effects. Ensure your healthcare provider is aware of all medications you are taking.

• Heart Rhythm Concerns: Invirase (saquinavir) may cause serious heart rhythm issues, especially if you have pre-existing heart conditions or electrolyte imbalances. Other medications that affect heart rhythm can exacerbate this risk. Seek immediate medical attention if you experience symptoms such as chest pain, palpitations, difficulty breathing, or dizziness.

• Blood Sugar Elevation: Protease inhibitors like Invirase (saquinavir) can raise blood sugar levels, potentially leading to or worsening diabetes. If you have a history of diabetes, inform your provider, who may recommend regular blood sugar monitoring.

• Liver Health: Liver problems have occurred in some users of Invirase (saquinavir). Pre-treatment and ongoing liver function tests are necessary. Report any symptoms of liver damage, such as fatigue, nausea, jaundice, or dark urine, to your provider immediately.

• Bleeding Risk in Hemophilia: Individuals with hemophilia may experience increased bleeding when taking protease inhibitors like Invirase (saquinavir). Notify your provider if you encounter unexpected or prolonged bleeding.

• Cholesterol Levels: Invirase (saquinavir) combined with ritonavir (Norvir) can elevate cholesterol and triglyceride levels. Regular blood tests are essential to monitor these levels. Avoid certain cholesterol medications like lovastatin and simvastatin while on Invirase (saquinavir).

• Lactose Intolerance: As Invirase (saquinavir) tablets contain lactose, individuals with lactose intolerance or certain genetic conditions should consult their provider before starting this medication.

• Immune System Changes: Combination antiretroviral therapy, including Invirase (saquinavir), may cause immune reconstitution syndrome, where the immune system becomes overly active. Report any new symptoms such as fever, pain, or other unusual signs to your provider.

• Body Fat Changes: Some people taking HIV medications, including Invirase (saquinavir), have experienced body fat redistribution. If you notice such changes, inform your healthcare provider.

Contraindications: Do not use Invirase (saquinavir) if you have a history of specific heart problems, low blood potassium or magnesium, severe liver issues, or if you are taking medications that interact with Invirase (saquinavir), such as amiodarone, lovastatin, or simvastatin.

In case of overdose or severe reactions, seek emergency medical assistance immediately. Always keep your healthcare provider informed about your health conditions and any other medications you are taking to ensure safe use of Invirase (saquinavir).

When taking this medication, some common side effects may occur, though they are generally mild. These include nausea, experienced by 11% of users, diarrhea by 8%, vomiting by 7%, stomach pain by 6%, and fatigue by 6%. Pneumonia and changes in body fat distribution are also reported by 5% of users. If these effects persist or worsen, consulting a healthcare provider is advisable.

Other side effects have been noted and should be monitored. These include constipation, fever, back pain, flu-like symptoms such as congestion and cough, rash, itching, dry lips, dry skin, and elevated blood sugar levels. Although these are typically manageable, seeking medical advice can help alleviate any discomfort.

Rare but serious side effects require immediate attention. These include severe liver problems, which might present as nausea, vomiting, loss of appetite, pain on the right side of the stomach, yellowing of the skin or eyes, dark urine, and light-colored stools. Additionally, abnormal heart rhythms may occur, indicated by chest pounding, trouble breathing, chest pain, faintness, or dizziness. It is crucial to seek urgent medical care if any of these symptoms are experienced.