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When considering the use of Dovato (dolutegravir / lamivudine), it is crucial to be aware of important safety information and warnings to ensure your well-being. Here is what you need to know:

• Hepatitis B and HIV: If you have both hepatitis B virus (HBV) and HIV, Dovato can lead to a worsening of hepatitis B symptoms. It is essential to test for HBV before starting treatment. Your healthcare provider will manage your treatment for both conditions. If you stop taking Dovato, your hepatitis symptoms may worsen. Consult your doctor before discontinuing the medication and seek immediate medical assistance if liver problems increase.

• Allergic Reactions: Rare but severe allergic reactions can occur. Be alert for symptoms such as severe rash, fever, discomfort, muscle pain, mouth sores, blisters, facial swelling, or difficulty breathing. If these occur, stop taking the medication immediately and seek medical attention.

• Liver Issues and Lactic Acidosis: Though uncommon, Dovato may lead to liver problems or lactic acidosis, especially if you also have hepatitis B or C. Discuss your medical history with your healthcare provider to ensure safe use.

• Immune System Changes: The medication can lead to immune reconstitution syndrome, where the immune system becomes more active and starts to fight off infections. This may cause the immune system to attack normal cells. Report any new symptoms such as fever, pain, or hair loss to your healthcare provider promptly.

• Drug Interactions: Dovato may interact with other medications, affecting its efficacy and risk of side effects. Inform your healthcare provider about any other medications you are taking.

• Pregnancy Risks: Taking Dovato during early pregnancy can increase the risk of neural tube defects. If you are of childbearing potential, a pregnancy test may be recommended before starting Dovato. Discuss birth control options and the risks and benefits of using Dovato during pregnancy with your provider.

• Contraindication: Do not use Dovato if you are taking dofetilide (Tikosyn), as it may pose serious health risks.

By following these guidelines and working closely with your healthcare provider, you can safely incorporate Dovato into your treatment plan.

When taking this medication, some individuals may experience common side effects, which are generally mild. These include headaches, trouble sleeping, feeling tired, nausea, diarrhea, anxiety, weight gain, dizziness, belly pain, vomiting, passing gas, and strange dreams. If these symptoms persist or worsen, it is advisable to consult with a healthcare provider for further guidance.

In some cases, this medication can lead to changes in blood levels, such as higher blood sugar, lower phosphate, higher creatine kinase, higher lipase levels, and abnormal liver function tests. Although these changes are often not severe, monitoring and consultation with a healthcare provider are recommended if they occur.

There are also rare but serious side effects that require immediate medical attention. These include severe allergic reactions characterized by fever, rash, extreme tiredness, body aches, mouth sores, blisters, or trouble breathing. Serious liver problems may manifest as nausea, vomiting, loss of appetite, right-sided stomach pain, yellowing of the skin or eyes, dark urine, and light-colored stools. Additionally, the buildup of lactic acid in the blood can occur, leading to weakness, tiredness, fast and shallow breathing, nausea, vomiting, a rapid heartbeat, and confusion.

Furthermore, as your immune system strengthens, it might react by fighting off existing infections, potentially causing symptoms of those infections to resurface. This can happen soon after beginning treatment or even months later. Symptoms of an overactive immune response, such as unexplained weight loss, severe tiredness, persistent muscle or joint pain, numbness or tingling, vision changes, or signs of infections, also warrant prompt medical attention. Rarely, this medication can cause severe nerve problems like Guillain-Barre syndrome, signaling a need for urgent care if symptoms arise.