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When taking this medication, you may experience mild side effects such as stomach pain, nausea, vomiting, heartburn, loss of appetite, or headache. These are generally not serious, but inform your healthcare provider if they persist or worsen. In some cases, as your immune system strengthens, it may react by fighting infections you previously had, potentially causing symptoms to return or appear anew.

Serious side effects require immediate medical attention. These include unexplained weight loss, severe fatigue, persistent muscle aches or weakness, severe headaches, joint pain, numbness or tingling in limbs, vision changes, or signs of infection like fever, swollen lymph nodes, and breathing difficulties. Be alert for signs of an overactive thyroid, such as irritability and irregular heartbeat, or symptoms of Guillain-Barre syndrome, which affects coordination and muscle control.

Severe side effects can include persistent nausea or vomiting, chest pain or discomfort suggestive of a heart attack, easy bruising or bleeding, abdominal pain, jaundice, dark urine, and signs of kidney issues like changes in urination. Indinavir may lead to kidney stones, so watch for pain in your side or back, pink or bloody urine, or painful urination.

There is a potential for increased blood sugar levels, possibly exacerbating diabetes. Be mindful of symptoms like increased thirst and urination. You might also notice changes in body fat distribution; the long-term effects of this are unclear, so discuss any concerns with your healthcare provider. Though rare, severe allergic reactions can occur, marked by rash, swelling, dizziness, or breathing difficulties. Seek help immediately if these occur. Always report any unusual side effects to your healthcare provider.