
Lopinavir-ritonavir Coupons & Savings Card – Discount Prices from $120.74
Generic for: Kaletra
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160ML of 400-100MG/5ML, Lopinavir-ritonavir (1 Bottle)
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CVS
$253.20
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Walgreens
$120.74
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Albertsons
$140.05
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Rite Aid
$366.54
COUPON PRICELopinavir-ritonavir savings card
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Walgreens
$120.74
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015995
LHKJN745981
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DR33
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Lopinavir-ritonavir dosage forms
Dosage | Quantity | Price from | Per unit |
---|---|---|---|
160ML of 400-100MG/5ML | 1 Bottle | $253.2 | $253.2 |
Lopinavir-ritonavir Warnings
This document outlines crucial safety information and warnings associated with the use of Kaletra (lopinavir/ritonavir). Please read the following points carefully and consult your healthcare provider if you have any questions or concerns.
Medication Interactions: Certain drugs can affect how Kaletra is processed in your body, potentially altering its effectiveness and increasing side effects. Discuss any other medications you are taking with your healthcare provider.
Pancreatitis Risk: Although rare, some individuals have developed pancreatitis while using Kaletra. Those with high triglycerides, advanced HIV, or a history of pancreatitis are at increased risk. Inform your provider immediately if you experience symptoms like upper stomach pain, fever, nausea, or vomiting.
Liver Issues: Kaletra usage has been linked to liver problems, which can be severe. These issues may occur shortly after beginning treatment or even after months. Regular blood tests will be conducted to monitor liver health. Symptoms to watch for include fatigue, nausea, appetite loss, light-colored stools, upper right stomach pain, jaundice, or dark urine.
Heart Rhythm Concerns: This medication may affect heart rhythm, posing serious risks. Individuals with existing heart conditions, electrolyte imbalances, or those on other heart-affecting medications are more susceptible. Seek immediate medical attention if you experience palpitations, difficulty breathing, chest pain, or dizziness.
Blood Sugar Levels: Kaletra can increase blood sugar levels, potentially exacerbating or leading to diabetes. If you have a history of diabetes, inform your provider. Monitoring blood sugar levels may be necessary.
Immune System Reaction: Kaletra, in combination with other HIV therapies, can cause an overactive immune response, known as immune reconstitution syndrome. This can lead to the immune system attacking normal cells. Report any new symptoms such as fever, pain, hair loss, bulging eyes, or sweating to your provider promptly.
Cholesterol and Triglycerides: This medication can raise cholesterol and triglyceride levels, heightening the risk of heart attack or stroke. Blood tests will be used to track these levels. Avoid using certain cholesterol medications like lovastatin and simvastatin while on Kaletra.
Body Fat Changes: Rarely, Kaletra may cause changes in body fat distribution, such as accumulation in specific areas or loss from others. Notify your provider if you notice such changes.
Bleeding Risks in Hemophilia: For those with hemophilia, Kaletra might increase bleeding risks. Report any unusual or persistent bleeding to your healthcare provider.
Newborn Risks: The oral solution of Kaletra contains ethanol and propylene glycol, which could be harmful to premature newborns. Avoid using the oral solution in premature babies unless necessary. Seek immediate help if the newborn shows signs of distress, such as difficulty breathing or feeding.
Contraindications: Do not use Kaletra with certain medications processed by the CYP3A4 liver enzyme, including alfuzosin, dronedarone, lovastatin, and simvastatin. Consult your healthcare provider if you are taking these or similar medications.
In case of an overdose, seek emergency medical attention immediately. Always follow your healthcare provider's instructions and ensure regular check-ups to monitor your health while using Kaletra.
Lopinavir-ritonavir Side Effects
Common side effects:
- Diarrhea
- Nausea
- Vomiting
- Headache
- Stomach upset
- Drowsiness
- Dizziness
- Bad taste in the mouth
Trouble sleeping
Less common but important to monitor:
- Changes in taste
- Respiratory tract infections
- Feelings of weakness
- Muscle pain
- Joint pain
- Back pain
- High cholesterol levels
- High triglyceride levels
Changes in body fat distribution
Serious side effects:
- Severe dizziness
- Fainting
- Heart rhythm changes
- Difficulty breathing
- Seizures
- Signs of kidney problems
- Unexplained weight loss
- Severe fatigue
- Persistent muscle aches
- Signs of infection
- Symptoms of a heart attack
- Severe allergic reaction
Lopinavir-ritonavir Interactions
Lopinavir/ritonavir, commonly known as Kaletra, can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. It's important to inform your healthcare provider about all the drugs and supplements you are currently taking, including over-the-counter medications and herbal products.
Some drugs should not be used with lopinavir/ritonavir as they may lead to serious interactions. These include medications such as alfuzosin, Alprazolam, Amiodarone, apalutamide, Rifampin, St. John's wort, and certain statins like Lovastatin and Simvastatin. These interactions can affect how lopinavir/ritonavir is processed in your body or how it influences other medications, potentially speeding up or slowing down their removal.
Additionally, lopinavir/ritonavir may reduce the effectiveness of hormonal contraceptives (like pills, patches, or rings), increasing the risk of unintended pregnancy. Discuss with your doctor about using additional reliable birth control methods.
Be cautious about using substances that cause drowsiness, including alcohol, cannabis, antihistamines, and certain medications for sleep or anxiety. Moreover, this drug can affect heart rhythm, so it's crucial to discuss any heart-related medications with your healthcare provider.
Always consult your doctor or pharmacist if you experience new symptoms or have concerns about possible interactions with other treatments you are using.
What is lopinavir and ritonavir used for?
Lopinavir and ritonavir are used in combination as an antiretroviral medication to treat and manage HIV-1 infection. They work by inhibiting the protease enzyme, which is essential for the replication of the virus, thereby helping to control the infection and improve immune function.
In which of the following patients would lopinavir and ritonavir be contraindicated?
Lopinavir and ritonavir would be contraindicated in patients with severe liver impairment, as these medications are metabolized by the liver. Additionally, they should not be used in patients who are taking medications that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. Examples include certain antiarrhythmics, ergot derivatives, and sedative/hypnotics. It is also contraindicated in patients with known hypersensitivity to any of the components of the formulation.
Why is lopinavir boosted with ritonavir?
Lopinavir is boosted with ritonavir to enhance its effectiveness. Ritonavir inhibits the enzyme CYP3A4, which is responsible for metabolizing lopinavir. By inhibiting this enzyme, ritonavir increases the concentration of lopinavir in the bloodstream, allowing for more effective viral suppression with lower doses of lopinavir. This combination is commonly used in the treatment of HIV.