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When using this medication, it is crucial to be aware of certain safety warnings and potential risks. Please read the following information carefully and discuss any concerns with your healthcare provider.

• Opioid Withdrawal: Naloxone may trigger sudden opioid withdrawal or reveal underlying pain in individuals who regularly use opioids or have received them during surgery. Symptoms may include pain, abdominal discomfort, diarrhea, rapid heartbeat, fever, sweating, nausea, vomiting, irritability, and trembling. In infants, these withdrawal symptoms can be life-threatening, potentially leading to seizures, excessive crying, and irregular reflexes. It is important to inform your healthcare provider immediately and closely monitor these symptoms, especially in infants and those who have just been administered naloxone. Those at risk include regular opioid users, infants under one month old who have received opioids, and individuals who have used opioids during surgery.

• Worsening Opioid Overdose Symptoms: Even if initial improvement is observed, symptoms of opioid overdose may worsen after naloxone administration, as its effects last only 30 to 90 minutes, whereas most opioids remain in the body longer. Always seek emergency medical help when an opioid overdose is suspected and stay with the affected person until help arrives. This is particularly important for those taking long-acting opioids.

• Limited Effectiveness: Naloxone may be less effective in reversing the effects of opioids with mixed activities, such as buprenorphine. Multiple doses of naloxone might be necessary in such cases, and each dose should use a new device or nasal spray. Those taking pain medications like buprenorphine or pentazocine are at risk.

• Heart Problems: If you have a history of heart issues or are on medications that could affect heart function, consult your healthcare provider before undergoing any surgery requiring opioid use. Naloxone, often used post-surgery, can cause serious heart complications, including seizures, irregular heartbeat, fluid accumulation in the lungs, or blood pressure changes. In rare instances, it may lead to brain damage, coma, or even death. Inform your provider of any heart history before any scheduled procedure. Those with a history of heart problems, taking heart-affecting medications, or using opioids during surgery are at increased risk.

Please ensure to follow these guidelines and communicate openly with your healthcare provider for safe and effective use of this medication.

When taking this medication, you may experience some common side effects, which are usually mild and temporary. These include nasal dryness, congestion, swelling, or pain, as well as headaches and a temporary increase in blood pressure. It's important to monitor these symptoms and consult your healthcare provider if they persist or worsen.

Less commonly, you might encounter nausea or feelings of dizziness and lightheadedness. While these symptoms can be uncomfortable, they are generally manageable. However, if you find them troubling, seeking advice from a healthcare professional is recommended.

On rare occasions, more serious side effects may occur, which require prompt medical attention. These include severe constipation, stomach pain, toothache, muscle spasms, and muscle pain. In individuals who have been using opioids regularly, sudden withdrawal symptoms can arise, including body aches, fever, sweating, and increased heart rate, among others. For infants younger than four weeks, sudden opioid withdrawal could be life-threatening and might manifest as seizures, excessive crying, or muscle twitching.

Though very rare, serious allergic reactions are possible. If you experience symptoms such as a rash, severe dizziness, or difficulty breathing, seek immediate medical help. Always stay informed about potential side effects and communicate with your healthcare provider to ensure your safety while using this medication.