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When using Relistor (methylnaltrexone), it is crucial to be aware of potential safety concerns. The following points outline important risks and precautions associated with this medication. If you have any questions or concerns, please consult your healthcare provider.

• Gastrointestinal Injury: Relistor may rarely cause serious injuries to the gastrointestinal tract, such as perforations. This risk is heightened if you have existing gastrointestinal conditions like cancer, ulcers, inflammation, or Crohn's disease. Discuss the risks and benefits with your healthcare provider if you have these conditions. Should you experience severe, persistent abdominal pain, discontinue use and seek medical attention immediately.

• Diarrhea: Severe, persistent diarrhea can occur with Relistor, potentially leading to dangerous dehydration. If you experience multiple instances of loose, watery stools, stop taking the medication and contact your healthcare provider promptly.

• Opioid Withdrawal: Relistor may induce symptoms of opioid withdrawal, such as sweating, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning. It may also reduce the effectiveness of opioid pain medications. If you notice withdrawal symptoms or diminished pain relief, speak with your healthcare provider for guidance.

Please ensure these precautions are carefully considered and discuss any concerns with your healthcare provider to ensure safe use of Relistor.

When taking this medication, you may experience some side effects, which are generally mild. Commonly reported side effects include abdominal pain, affecting 14-29% of users, diarrhea in 5-6%, and nausea, particularly with the injection form, in 9-12% of cases. These symptoms are typically manageable, but should they persist or worsen, it's important to inform your healthcare provider.

In addition to these, other side effects have been observed, though they are less common. These can include headache, a feeling of abdominal bloating, vomiting, sweating, anxiety, muscle spasms, a runny nose, chills, hot flashes, tremors, and dizziness. While these may not be as frequent, you should report them to your healthcare provider if they occur.

There are also rare but serious side effects associated with this medication that require immediate medical attention. Severe abdominal pain could indicate injury to the stomach or intestines, and severe diarrhea are both urgent issues. It's critical to seek medical help promptly if you experience these symptoms.