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You may experience mild side effects like stomach or abdominal pain, nausea, gas, dizziness, fever, or diarrhea. Additionally, you might notice pain, redness, or swelling at the injection site. These effects are usually temporary, but if they persist or worsen, it's important to inform your healthcare provider.

To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions. While many individuals taking this medication do not experience severe side effects, it's crucial to monitor your symptoms. Should you have persistent diarrhea, stop taking methylnaltrexone and consult your doctor immediately.

Opioid withdrawal symptoms can occur in some people, so if you notice symptoms such as sweating, chills, abdominal cramps, diarrhea, mood changes (such as anxiety or confusion), extreme drowsiness, or hallucinations, seek medical advice promptly.

In rare instances, this medication may cause a serious condition like a tear in the stomach or intestinal wall. If you experience severe and persistent stomach or abdominal pain, fever, severe dizziness, fainting, or intense nausea or vomiting, discontinue use and obtain medical help right away.

Though a very serious allergic reaction is uncommon, be vigilant for symptoms such as rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. Seek immediate medical attention if these occur. If you experience any other side effects not mentioned, reach out to your healthcare provider for guidance.