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Pain in the stomach/abdomen, diarrhea, or gas may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Opiate withdrawal symptoms may occur in some people. Tell your doctor right away if any of these withdrawal symptoms occur: sweating, chills, pain in the stomach/abdomen, diarrhea, yawning, mental/mood changes (such as anxiety/irritability). This drug may rarely cause a serious tear in the stomach or intestinal wall (perforation). If you notice any of the following unlikely but serious side effects, get medical help right away: severe stomach/abdominal pain that doesn't go away, fever, dizziness/fainting, nausea/vomiting. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Other medications can affect the removal of naloxegol from your body, which may affect how naloxegol works. Examples include adagrasib, azole antifungals (such as ketoconazole, itraconazole), clarithromycin, cobicistat, indinavir, nefazodone, nelfinavir, rifamycins (such as rifampin, rifabutin), ritonavir, tipranavir, among others.