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Fenoprofen (Nalfon) is a nonsteroidal anti-inflammatory drug (NSAID) that may pose several risks and requires careful consideration and monitoring. Below are important safety warnings and precautions for its use:

• Cardiovascular Risks: Fenoprofen may increase the risk of heart attacks or strokes, particularly with prolonged use. This risk is heightened in older adults, those with a history of heart disease, or individuals undergoing heart bypass surgery. Use the lowest effective dose for the shortest duration possible to minimize these risks. It is not recommended before or after heart bypass surgery.

• Gastrointestinal Bleeding: There is a risk of severe and potentially fatal bleeding in the stomach or intestines, which can occur without warning. This risk is greater in older adults and those with a history of gastrointestinal issues or who use certain other medications. Seek immediate medical attention if you experience persistent stomach pain, black or tarry stools, or vomiting blood.

• Blood Pressure and Heart Failure: Fenoprofen can increase blood pressure and exacerbate heart failure symptoms, such as fluid retention. Regular monitoring of blood pressure is advised, and patients with heart failure should discuss the risks and benefits with their provider.

• Kidney and Liver Function: This medication may impair kidney and liver function, particularly in those with pre-existing conditions or who are taking other medications affecting these organs. Report symptoms like reduced urine output, nausea, or jaundice to your healthcare provider promptly.

• Allergic Reactions and Skin Reactions: Serious allergic reactions may occur, especially in individuals with known allergies to aspirin or other NSAIDs. Life-threatening skin reactions are also possible. Discontinue use and seek medical help if hives, difficulty breathing, or severe skin rashes occur.

• Pregnancy Warning: Fenoprofen is not recommended during pregnancy, especially in the third trimester, due to potential harm to the unborn baby. Pregnant individuals should consult their healthcare provider for safer alternatives.

• Anemia and Vision Changes: The risk of anemia due to bleeding exists, and regular blood tests may be needed. Although rare, changes in vision have been reported with NSAID use, so any unusual eye symptoms should be evaluated by an eye specialist.

In case of overdose or any serious side effects, seek emergency medical assistance immediately. Always discuss with your healthcare provider to thoroughly understand the benefits and risks of using fenoprofen.

When taking this medication, some individuals may experience common side effects such as upset stomach, constipation, nausea, drowsiness, dizziness, headache, nervousness, and blurred vision. These effects often resolve on their own, but if they persist or worsen, consult your healthcare provider. Additionally, swelling of the legs or hands, weakness, and sleepiness can occur in a small percentage of users.

While many people do not experience serious side effects, it is important to be aware of them. This medication can raise blood pressure, so regular monitoring is advised. Serious side effects that require immediate medical attention include changes in hearing, mental or mood changes, easy bruising or bleeding, and signs of heart failure, such as swelling of the ankles or feet, unusual tiredness, and sudden weight gain.

Rarely, this medication can cause severe liver or kidney problems, manifested by symptoms like persistent nausea, vomiting, loss of appetite, yellowing of the skin or eyes, dark urine, and changes in urine output. Additionally, serious allergic reactions, though rare, necessitate urgent medical care if symptoms like rash, severe dizziness, difficulty breathing, or swelling of the face, tongue, or throat occur.

Finally, other rare but serious conditions include heart attack, stroke, and gastrointestinal bleeding. Look out for symptoms such as chest pain, shortness of breath, black or tarry stools, and slurred speech. Always communicate with your healthcare provider about any unusual symptoms to ensure your safety.

Fenoprofen, also known as Nalfon, can interact with a range of other medications. It's important to inform your doctor and pharmacist about any medications or supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal supplements.

Certain medications should not be taken with fenoprofen, and your doctor might choose alternative treatments. For instance, ketorolac should be avoided.

Some medications, although generally not recommended with fenoprofen, may still need to be used together in specific situations. Your doctor might adjust the dosage or frequency of either medication. This includes drugs such as abciximab, amiloride, amitriptyline, aspirin, clopidogrel, corticosteroids like dexamethasone and prednisone, dabigatran, enoxaparin, furosemide, lithium, methotrexate, and warfarin, among others.

Additionally, using fenoprofen with certain other drugs can increase the risk of side effects, yet might be necessary for your treatment. In such cases, your doctor could modify the dosage or administration schedule. These drugs include beta blockers like atenolol and metoprolol, ACE inhibitors such as captopril and lisinopril, and angiotensin II receptor blockers like losartan and valsartan.

It's also important to be aware that fenoprofen can increase the likelihood of bleeding, especially when combined with other medications that have similar effects, like anti-platelet drugs and blood thinners.

Lastly, fenoprofen may affect the results of certain lab tests, such as those for thyroid hormones. Be sure to inform your healthcare provider and any lab personnel that you are taking this medication.