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When using Nourianz (istradefylline), it is crucial to be aware of the following safety information to ensure proper use and manage any potential risks. Please review these points and discuss any concerns with your healthcare provider.

• Movement Disorders (Dyskinesia): This medication may cause or exacerbate involuntary movements, known as dyskinesia, which can affect various parts of your body, including the face, arms, legs, or torso. If you have a history of dyskinesia, inform your healthcare provider prior to starting treatment.

• Psychiatric Effects: Nourianz can potentially intensify mental health issues such as hallucinations, aggressive behavior, delusional thoughts, and mania. These symptoms can occur even in individuals without previous mental health diagnoses. Should you experience any of these issues, contact your provider immediately as they may need to adjust your dosage or discontinue the medication.

• Compulsive Behaviors: Some individuals may develop compulsive behaviors, such as gambling, increased sexual urges, excessive shopping, or binge eating while on this medication. If you notice new or uncontrollable urges, or if others observe changes in your behavior, notify your healthcare provider. Medication adjustments may be necessary.

Please ensure your family and caregivers are also informed so they can help monitor any behavioral changes. Always consult your healthcare provider for guidance tailored to your specific health needs.

When taking this medication, you may experience some common side effects, which are typically mild. These include dizziness, constipation, and decreased appetite. If these effects persist or become bothersome, it is advisable to consult your healthcare provider. Additionally, some individuals might encounter nausea, hallucinations, or insomnia, but these are less common.

There are other side effects that have been reported, such as uncontrolled movements, skin rash, and diarrhea. While these are usually not severe, it is important to monitor them and seek medical advice if they occur. It is also noted that some individuals might experience problems related to mood and behavior, including anxiety, irritability, and hallucinations.

Serious side effects, although rare, necessitate immediate medical attention. These include severe allergic reactions characterized by rash, itching, or swelling of the face, lips, tongue, or throat. Furthermore, new or worsening uncontrolled movements, significant mood changes, or impulsive behaviors such as gambling or binge eating require urgent care. If you notice any of these, seeking prompt medical assistance is crucial.