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Here are important safety warnings and precautions for using Osmolex ER (amantadine). Please read them carefully and discuss any concerns with your healthcare provider.

• Daytime Sleepiness: Osmolex ER can cause unexpected sleepiness during daily activities, which may lead to accidents, especially when driving or operating machinery. Those with a history of sleep disorders or who are taking drowsiness-inducing medications should exercise caution. Alcohol can intensify this effect, so it should be avoided. Refrain from activities requiring full alertness until you understand how the medication affects you. Report any instances of falling asleep unexpectedly to your provider immediately.

• Suicidal Thoughts or Behavior: There is a potential risk of increased suicidal thoughts or behaviors, particularly if you have a history of depression. Monitor for any worsening of depression or unusual changes in mood, especially at the start of treatment or when adjusting the dose. Promptly report any concerning behavior to your healthcare provider.

• Mood Changes and Hallucinations: The medication may cause hallucinations, mood changes, confusion, agitation, or aggressive behavior due to increased dopamine levels. If you have a history of psychosis or are altering your medication regimen, the risk is heightened. Inform your provider of any mental health conditions before starting treatment.

• Low Blood Pressure and Dizziness: Osmolex ER may cause low blood pressure, leading to dizziness or fainting. Alcohol consumption and higher doses increase this risk. Share your full medical history and current medications with your provider to assess the safety of this treatment for you.

• Withdrawal Symptoms: Abruptly stopping or reducing the dose of Osmolex ER can lead to severe withdrawal symptoms, resembling neuroleptic malignant syndrome (NMS), or worsening Parkinson’s disease symptoms. Symptoms may include high fevers, confusion, muscle stiffness, and blood pressure changes. Do not discontinue or adjust your dosage without medical guidance.

• Impulsive Behaviors: Some users may experience uncontrollable urges, such as excessive gambling, spending, or eating. These behaviors can be mitigated by adjusting the dosage or discontinuing the medication. Discuss any observed changes with your healthcare provider, who may inquire about these behaviors during follow-ups.

• Contraindications: Osmolex ER should not be used in individuals with end-stage kidney disease due to serious health risks. Consult with your healthcare provider if this applies to you.

When taking this medication, some individuals may experience common side effects such as nausea, dizziness, trouble sleeping, dry mouth, constipation, and headaches. These effects are typically mild and temporary, but if they persist or worsen, it is important to consult your healthcare provider. To ease dry mouth, consider sipping water, chewing sugarless gum, or using a saliva substitute.

More uncommon effects include loss of appetite, drowsiness, lightheadedness, and strange dreams. Additionally, some individuals may experience mood changes such as depression, anxiety, or agitation. If you notice web-like purple-blue skin discoloration (livedo reticularis) or feel unusually tired, it's advisable to inform your healthcare provider.

Serious side effects, while rare, must be addressed immediately. These include signs of a severe allergic reaction such as rash, swelling, or trouble breathing, as well as neurological symptoms like seizures or sudden sleep episodes during daily activities. If you experience severe mood changes, hallucinations, or unusual urges, such as increased gambling or sexual urges, seek prompt medical attention.

In extremely rare cases, conditions such as Neuroleptic Malignant Syndrome (NMS) may occur, marked by high fevers, muscle stiffness, or irregular heartbeat. Suicidal thoughts or behaviors also demand urgent care. If you suspect an overdose, characterized by fast heartbeat or difficulty breathing, immediate medical intervention is critical.

Overall, while this medication can cause side effects, many individuals do not experience severe issues and find the benefits to outweigh the risks. Always report unfamiliar or concerning reactions to your healthcare provider for proper assessment and guidance.

Amantadine can interact with various substances, affecting how it works with other medications and vaccines. If you are using Osmolex ER (amantadine), it's important to inform your doctor and pharmacist about any other medications or supplements you are taking, including prescribed drugs, over-the-counter medications, vitamins, and herbal supplements.

Amantadine may reduce the effectiveness of certain vaccines, such as the nasal flu vaccine. However, receiving a flu shot via injection may still be safe if your doctor advises it.

Certain drugs should be avoided with amantadine. Potassium Chloride is one such medication where concurrent use is generally not recommended. For other drugs like Amifampridine, Bupropion, Donepezil, Glucagon, Memantine, Methacholine, Metoclopramide, Quetiapine, and Secretin Human, it is usually advised against using them with amantadine, unless necessary. If your doctor prescribes these together, they might adjust the dosage or frequency.

Additionally, some medications like Betel Nut, Bromperidol, Triamterene, and Trimethoprim can increase the risk of side effects when used with amantadine. In such cases, your doctor might modify how you take these medications to ensure the best treatment outcome. Always consult your healthcare provider before making any changes to your medication routine.