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When taking this medication, you might experience some common side effects like diarrhea, nausea, vomiting, dizziness, lightheadedness, drowsiness, stomach upset, loss of appetite, trouble sleeping, headache, or dry mouth. These effects are generally mild, but if they persist or worsen, it's important to speak with your healthcare provider. You might also notice a harmless darkening of saliva, urine, or sweat, which could stain clothing.

To help minimize dizziness and lightheadedness, try standing up slowly from sitting or lying down. Although many individuals do not encounter serious side effects, some may experience increased sleepiness and unexpected sleep episodes during daily activities. Avoid driving or engaging in potentially hazardous tasks if this occurs, and discuss it with your healthcare provider, especially if you consume alcohol or other drowsiness-inducing medications.

Serious side effects that require immediate medical attention include new or worsening uncontrollable movements, significant eye blinking or twitching, persistent diarrhea, vision changes, severe stomach pain, black stools, vomit resembling coffee grounds, muscle pain or weakness, kidney issues, mental changes, infections, unusual bleeding, fatigue, tingling in extremities, and intense urges like gambling or increased sexual desire.

In rare cases, stopping or reducing the medication can lead to neuroleptic malignant syndrome (NMS), a severe condition marked by symptoms such as fever, unusual muscle stiffness, severe confusion, sweating, and a fast or irregular heartbeat. Seek urgent medical help if these occur. Additionally, though very rare, serious allergic reactions may manifest as rash, swelling, severe dizziness, or breathing difficulties, requiring prompt medical attention. Always consult your healthcare provider if you notice any unlisted or concerning effects.

This medication can interact with a variety of other drugs. Specifically, certain medications for high blood pressure, like methyldopa, may have interactions. Additionally, taking MAO inhibitors with this drug can lead to a serious, potentially life-threatening reaction. You should not use MAO inhibitors like isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, or tranylcypromine while on this medication, and most should be avoided for at least two weeks before starting treatment. However, some MAO inhibitors such as rasagiline, safinamide, and selegiline may be used if your doctor closely monitors your condition. Always consult your doctor about when to start or stop this medication.

Inform your healthcare provider if you are using any substances that cause drowsiness, including alcohol, marijuana, certain antihistamines (like cetirizine, diphenhydramine), sleep or anxiety medications (such as alprazolam, diazepam, zolpidem), muscle relaxants (like carisoprodol, cyclobenzaprine), and opioid pain medications (such as codeine, hydrocodone).

Be sure to check the labels on all your medications, including those for allergies or cough-and-cold, as they may contain ingredients that could cause drowsiness. Discuss with your pharmacist how to use these products safely.

Lastly, this medication may affect the results of certain laboratory tests, such as urine catecholamine, glucose, or ketone tests, potentially leading to inaccurate results. Ensure that all your healthcare providers and laboratory personnel are aware of your medication use.