Entacapone

Drug Details

Entacapone, marketed as Comtan, is prescribed for individuals with Parkinson's disease to enhance the effectiveness of the medication combination carbidopa/levodopa. This drug is especially beneficial for those experiencing "wearing-off" symptoms, where the effects of levodopa diminish before the next dose. Entacapone works by inhibiting the enzyme catechol-O-methyltransferase (COMT), which breaks down levodopa in the body. By blocking this enzyme, entacapone helps maintain higher levels of levodopa, allowing it to act longer and more effectively in alleviating symptoms such as tremors and slow movement. It is important to take entacapone with each dose of carbidopa/levodopa for optimal results. Potential side effects may include involuntary movements and nausea. Always consult with a healthcare provider to ensure the safe and effective use of this medication.