Parkinson's DiseaseEntacapone coupons
Entacapone

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generic Comtan

This medication is used with other medications (levodopa/carbidopa) to treat Parkinson's disease. Entacapone belongs to a class of drugs known as COMT inhibitors. Many people taking levodopa for Parkinson's have problems with the effects of the levodopa wearing off between scheduled doses, causing symptoms to return or worsen. Entacapone blocks a certain natural substance (COMT enzyme) that breaks down the levodopa in the body. This effect allows the levodopa to last longer in the system so that it doesn't wear off before the next dose.
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Entacapone Side EffectsEntacapone InteractionsFAQs

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200MG, Entacapone (30 Tablets)

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CVS

$23.19

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$14.02

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$14.70

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$27.09

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$33.40

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Entacapone dosage forms

The average cost for 30 Tablets of Entacapone (generic Comtan) at 200MG is $13.9 with a free coupon. This is 12.26% off the average retail price of $113.4
DosageQuantityPrice fromPer unit
200MG30 Tablets$13.9$0.46

Entacapone Side Effects

Nausea, vomiting, diarrhea, unwanted/uncontrolled movements, increased sweating, drowsiness, tiredness, dry mouth, gas, and abdominal pain may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Lightheadedness or dizziness upon standing may also occur, especially during the first few weeks of treatment. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Your urine may turn brownish-orange. This effect is harmless. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Some people taking entacapone have fallen asleep suddenly during their usual daily activities (such as talking on the phone, driving). In some cases, sleep occurred without any feelings of drowsiness beforehand. This sleep effect may occur anytime during treatment with entacapone even if you have used this medication for a long time. If you experience increased sleepiness or fall asleep during the day, do not drive or take part in other possibly dangerous activities until you have discussed this effect with your doctor. Your risk of this sleep effect is increased by using alcohol or other medications that can make you drowsy. Tell your doctor right away if you have any serious side effects, including: diarrhea that doesn't stop, mental/mood changes (such as confusion, hallucinations), unusual strong urges (such as increased gambling, increased sexual urges), fever, muscle stiffness, easy bleeding/bruising, sore/painful muscles, muscle weakness, trouble breathing, pain with breathing. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Entacapone Interactions

Some of the products that may interact with this drug include: certain MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, tranylcypromine). Other MAO inhibitors (safinamide, selegiline, rasagiline) may be used cautiously with close monitoring by your doctor. If you are taking rasagiline or selegiline for Parkinson's disease, ask your doctor if you should keep taking it. Entacapone can slow down the removal of other drugs from your body, thereby affecting how they work. These affected drugs include apomorphine, dobutamine, and methyldopa. This is not a complete list. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Entacapone FAQs
What is the difference between entacapone and carbidopa?

Entacapone and carbidopa are both medications used in the management of Parkinson's disease, but they have different mechanisms of action. Entacapone is a COMT (catechol-O-methyltransferase) inhibitor that works by preventing the breakdown of levodopa, thereby increasing its availability in the brain. Carbidopa, on the other hand, is a DOPA decarboxylase inhibitor that prevents the conversion of levodopa to dopamine outside the brain, allowing more levodopa to reach the brain and reducing peripheral side effects.

Entacapone may cause several adverse effects, including nausea, diarrhea, dizziness, abdominal pain, dry mouth, and urine discoloration. It can also lead to more serious effects such as dyskinesia, hallucinations, and confusion. Patients should be monitored for these effects, and any concerning symptoms should be reported to a healthcare provider.

Entacapone is used in the management of Parkinson's disease to enhance the effectiveness of levodopa/carbidopa therapy. It works by inhibiting the enzyme catechol-O-methyltransferase (COMT), which breaks down levodopa in the body. This results in increased levels of levodopa reaching the brain, thereby improving the control of motor symptoms associated with Parkinson's disease.

Entacapone is important for Parkinson's patients because it helps to enhance the effectiveness of levodopa, a common medication used to manage Parkinson's symptoms. By inhibiting the enzyme catechol-O-methyltransferase (COMT), entacapone reduces the breakdown of levodopa in the body, allowing more of it to reach the brain. This can help to improve motor function and reduce the "wearing-off" effect that some patients experience between doses of levodopa.

When taking entacapone, it is important to monitor liver function, as the medication can affect liver enzymes. Additionally, patients should be observed for any signs of dyskinesia, as entacapone can increase the effects of levodopa. Monitoring for any unusual side effects or changes in symptoms is also recommended. Regular follow-up with a healthcare provider is advised to ensure the medication is working effectively and safely.

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