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Upadacitinib is a medication that requires careful consideration of safety information due to potential risks. Below are important warnings and precautions to keep in mind while using this medication:

• Risk of Infections: Upadacitinib may impair your immune system, increasing the risk of serious infections such as pneumonia and skin infections. This risk is heightened if you are also taking other immunosuppressive drugs like methotrexate or corticosteroids. It is crucial to inform your doctor immediately if you experience signs of infection, such as persistent sore throat, fever, chills, cough, non-healing skin sores, painful urination, or oral white patches. Routine tuberculosis (TB) testing is advised before and during treatment, especially if you have been in areas with common fungal infections.

• Cancer Risk: There's a potential risk of developing cancers such as lymphoma and skin cancer, especially if you have a history of smoking. Protect your skin from UV exposure by using sunscreen and wearing protective clothing. Consult your doctor if you notice any changes in moles, unusual skin changes, or persistent symptoms like fever or cough.

• Blood Clots: Rare but serious blood clot events have been reported, including heart attacks and strokes. The risk is higher in individuals over 50, smokers, or those with heart disease risk factors. Seek immediate medical assistance if you experience symptoms such as chest pain, sudden dizziness, or weakness on one side of the body.

• Allergic Reactions: Upadacitinib may cause severe allergic reactions, including anaphylaxis. If you experience rash, difficulty breathing, or swelling of the face, tongue, or throat, seek emergency medical help immediately.

• Gastrointestinal Issues: Some patients have reported stomach or gut tears. Notify your provider if you've had prior gut issues or are taking NSAIDs, as these may increase your risk. Symptoms such as new stomach pain, fever, or blood in stools warrant urgent medical attention.

• Abnormal Lab Results: Rarely, this medication can lead to abnormal blood cell counts, potentially causing infections or anemia. Regular blood tests are recommended to monitor this. Report any unusual frequency of illness to your healthcare provider.

• Pregnancy Considerations: Animal studies suggest potential harm to unborn babies from upadacitinib. Avoid pregnancy during treatment and for four weeks afterward. Your doctor may recommend a pregnancy test before starting treatment.

• Medication in Stool: Some patients report seeing the medication in their stool, which may suggest absorption issues. If this occurs frequently and you do not see improvement from the medication, discuss alternative treatments with your healthcare provider.

Consult your healthcare provider for further guidance and discuss any concerns or pre-existing conditions that might affect your treatment with upadacitinib.

When taking this medication, you might experience some common side effects, which are generally mild. These include upper respiratory tract infections, acne, herpes simplex virus infections, and headaches. If these persist or become bothersome, it's advisable to consult a healthcare provider. Additionally, other side effects such as cough, nausea, stomach pain, fever, weight gain, flu-like symptoms, tiredness, muscle pain, swollen hair follicles, rash, and herpes zoster infection may occur. Again, if these side effects are concerning, seek advice from a healthcare professional.

There are more serious side effects that, although rare, demand immediate medical attention. These include signs of serious infections like fever, chills, difficulty breathing, and stomach pain, among others. Stroke symptoms such as sudden weakness, trouble speaking, or confusion also fall into this category. Blood clots are another serious concern, with symptoms varying based on location, including chest pain, shortness of breath, or leg pain. Watch for signs of a stomach tear, such as persistent stomach pain and bloating. Lastly, severe allergic reactions, though rare, need urgent medical care and include symptoms like rash, trouble breathing, or swelling of the face or throat.

It's important to be vigilant for any unusual symptoms and contact a healthcare provider if you experience side effects not listed above. While the risk of side effects exists, monitoring and prompt attention to symptoms can help manage them effectively.