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Here are important safety warnings and precautions related to the use of Tamiflu (oseltamivir). Please ensure you discuss any concerns with your healthcare provider.

• Severe Skin and Allergic Reactions: Rarely, Tamiflu can cause serious skin conditions such as Stevens-Johnson syndrome (SJS), which manifests as painful rashes and blisters. An allergic reaction, including anaphylaxis, is also possible. Seek immediate medical help if you experience severe rashes, fever, blisters, mouth sores, facial swelling, or breathing difficulties. Individuals with a history of severe allergic reactions to Tamiflu are at increased risk.

• Behavioral Changes and Hallucinations: Some users, particularly children, have reported unusual behavior and hallucinations. These symptoms may be linked to either Tamiflu or the influenza virus itself. Although these symptoms typically resolve quickly, they can occasionally lead to dangerous situations. Contact your healthcare provider if you notice changes in mental clarity, behavior, speech, tremors, seizures, or hallucinations.

• Interaction with Nasal Spray Flu Vaccine: Tamiflu may reduce the effectiveness of the live attenuated influenza vaccine (LAIV), commonly known as the nasal spray flu vaccine. It is advisable to wait 48 hours after completing Tamiflu treatment before receiving the nasal spray vaccine. If you have recently received the vaccine within two weeks of starting Tamiflu, consult your healthcare provider for guidance.

• Bacterial Infections: Tamiflu is not effective against bacterial infections and might not address flu-like symptoms caused by bacteria. If your symptoms worsen or you develop new symptoms such as fever or chills, notify your healthcare provider as these may indicate a new or different infection.

• Hereditary Fructose Intolerance: The liquid form of Tamiflu contains sorbitol, which could cause stomach upset and diarrhea in individuals with hereditary fructose intolerance. If needed, the capsule form can be used as an alternative, as they can be opened and mixed with a sweetened syrup. Additionally, compounding pharmacies may be able to provide a sorbitol-free liquid formulation. It is important to inform your healthcare provider and pharmacist about any fructose intolerance.

Common side effects:

• Nausea
• Vomiting
• Headaches

Serious side effects:

• General pain
• Confusion
• Agitation
• Self-injury
• Serious allergic reaction
• Rash
• Itching
• Swelling of the face, tongue, or throat
• Severe dizziness
• Difficulty breathing

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Warfarin