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This medication comes with several important safety warnings that you should thoroughly review. If you have any concerns, discuss them with your healthcare provider.

• Daytime Sleepiness: Amantadine can cause sudden sleepiness during daily activities, which may lead to accidents, especially when driving or operating machinery. Avoid alcohol as it can increase drowsiness. Consult your healthcare provider if you have a history of sleep disorders or are taking sedatives. Refrain from activities requiring full alertness until you understand how the medication affects you. Report any incidents of falling asleep during normal activities to your provider immediately.

• Suicidal Thoughts or Behavior: There is an increased risk of suicidal thoughts or behavior, particularly if you have a history of depression. Be vigilant for worsening depression or unusual mood changes, especially at the start of treatment or when adjusting the dose. Report any concerning changes to your healthcare provider without delay.

• Mood Changes and Hallucinations: Amantadine may cause hallucinations or mood changes, such as confusion, agitation, or aggressive behavior, particularly in individuals with a history of psychosis or when the medication is abruptly stopped. Inform your provider of any mental health conditions before starting treatment.

• Low Blood Pressure and Dizziness: The medication may lower blood pressure, increasing the risk of fainting. Discuss your medical history and current medications with your provider to assess safety. Avoid alcohol and be cautious with higher doses.

• Withdrawal Symptoms: Abrupt discontinuation or dose reduction can lead to symptoms akin to neuroleptic malignant syndrome (NMS), a life-threatening condition. Symptoms include high fever, confusion, irregular pulse, muscle stiffness, and changes in blood pressure. Do not stop or adjust your dose without consulting your provider.

• Impulsive Behaviors: Amantadine may lead to impulse control issues, such as strong urges to gamble, shop, or binge eat. If these behaviors negatively impact your life, consult your provider. Adjusting or stopping the medication may help.

• Overdose Risk: There is a rare risk of death from overdose, particularly in individuals with kidney problems. Take the medication exactly as prescribed. Inform your provider of any kidney disease history to ensure proper dosing.

• Seizures: If you have a history of seizures or are on seizure control medications, amantadine may increase seizure risk. Seek immediate medical attention if a seizure occurs during treatment.

• Heart Failure: Some individuals have experienced heart failure while on amantadine. The risk is higher for those with a history of heart failure or swelling in limbs. Report any shortness of breath or limb swelling to your provider.

• Kidney Impairment: Since amantadine is eliminated by the kidneys, those with kidney problems or individuals over 65 may experience increased side effects. Your provider may adjust your dose accordingly.

• Liver Concerns: Although rare, liver problems can occur. If you have a history of liver disease, your provider may need to monitor your liver function through blood tests.

• Skin Cancer Risk: There is a potential increased risk of skin cancer in individuals with Parkinson's disease. Report any new or unusual skin growths or changes in moles to your provider, who may suggest periodic skin examinations during treatment.

Please ensure you follow these precautions and consult your healthcare provider regularly while using this medication.

Common side effects:

• blurred vision
• nausea
• dizziness
• headache
• dry mouth
• constipation
• trouble sleeping
• drowsiness
• nervousness

Less common but important to monitor:

• depression
• anxiety
• unusual dreams
• lack of appetite
• dry nose
• fatigue

Serious side effects:

• suicidal thoughts
• severe mood changes
• seizures
• neuroleptic malignant syndrome
• purplish-red spots on the skin
• swelling of the ankles or feet
• vision changes
• difficulty urinating
• sudden sleep onset during daily activities
• allergic reaction (rash, severe dizziness, breathing difficulties)

Interactions with high risk of serious adverse effects and should be avoided:

• Potassium Chloride

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amifampridine
• Bupropion
• Donepezil
• Glucagon
• Memantine
• Methacholine
• Metoclopramide
• Quetiapine
• Secretin Human

Interactions with low risk that usually do not require a change in therapy:

• Betel Nut
• Bromperidol
• Triamterene
• Trimethoprim