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Oyster shell calcium with vitamin D can cause some side effects. Common side effects may include constipation, gas, and an upset stomach. Less common but more serious side effects can include high levels of calcium in the blood, which may present as nausea, vomiting, loss of appetite, increased thirst or urination, and confusion. If any severe side effects occur, it is important to seek medical attention promptly.

Individuals who should avoid taking oyster shell calcium include those with a known allergy to shellfish, as it may trigger an allergic reaction. Additionally, people with hypercalcemia (high levels of calcium in the blood) or those with a history of kidney stones should consult a healthcare provider before using this supplement. It is also important for individuals with kidney disease or those taking certain medications that interact with calcium to seek medical advice prior to use. Pregnant or breastfeeding women should discuss with their healthcare provider to ensure safety.

Calcium derived from oyster shells is generally considered safe for most people when taken in appropriate amounts. However, it is important to ensure that the oyster shell calcium supplements are from a reputable source to avoid contamination with heavy metals such as lead. Individuals with shellfish allergies should avoid these supplements. It is always advisable to consult with a healthcare provider before starting any new supplement to ensure it is appropriate for one's specific health needs.

Oyster calcium, like other calcium supplements, can potentially cause constipation in some individuals. It is important to maintain adequate hydration and consider dietary fiber intake to help manage this side effect. If constipation persists, consulting a healthcare provider for further advice would be beneficial.