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Antidepressant medications are prescribed to manage depression and various mental or mood disorders. They offer significant benefits, such as reducing the risk of suicidal thoughts or actions. However, it's essential to acknowledge that a small percentage of individuals, particularly those under 25, may experience a worsening of depression, mood symptoms, or suicidal thoughts while using these medications.

Key Safety and Warning Information:

• Discuss with your healthcare provider the potential risks and benefits of antidepressants, especially if you are under 25 or if the medication is prescribed for conditions other than mental or mood disorders.
• Immediately inform your doctor if you observe any deterioration in depression or other psychiatric symptoms, unusual behavioral changes, or emergence of suicidal thoughts or actions.
• Remain vigilant for symptoms such as increased anxiety, panic attacks, difficulty sleeping, irritability, feelings of anger or hostility, impulsive behavior, severe restlessness, or rapid speech, particularly when starting a new antidepressant or adjusting the dosage.
• Close monitoring is crucial when initiating treatment or modifying the dose to promptly address any adverse effects.

This information is vital for ensuring the safe and effective use of antidepressant medications.

You may experience dizziness, drowsiness, tiredness, weakness, difficulty sleeping, constipation, or a dry mouth. These are common side effects and usually not a cause for concern. However, should they persist or worsen, it is important to inform your healthcare provider.

To minimize the chances of dizziness and lightheadedness, try rising slowly from sitting or lying down. It's important to know that many individuals taking this medication do not experience significant side effects, as the benefits often outweigh the risks.

Nonetheless, be vigilant for serious side effects such as fainting, mental changes like agitation or confusion, muscle stiffness, altered sexual interest, shaking, shivering, swollen limbs, sudden weight changes, eye discomfort, vision issues, or signs of liver trouble like persistent nausea, abdominal pain, yellowing skin, or dark urine. These warrant immediate medical attention.

In rare instances, this medication can trigger a hypertensive crisis, a potentially life-threatening condition. Symptoms include severe headache, irregular heartbeat, chest pain, neck soreness, severe nausea, sweating, widened pupils, or sensitivity to light. Seek immediate help if these occur.

Serotonin syndrome is a rare but serious condition that may develop, especially if you're on other serotonin-increasing drugs. Look out for rapid heartbeat, hallucinations, coordination loss, severe dizziness, nausea, muscle twitching, unexplained fever, or restlessness, and seek urgent care if these arise.

Although allergic reactions to this drug are very uncommon, they require immediate medical intervention if you notice a rash, itching, swelling of the face or throat, dizziness, or breathing difficulties.

This summary doesn't cover all possible side effects. If you observe any unusual symptoms, contact your healthcare provider for guidance.

Certain medications may interact with this drug. These include other antidepressants like Maprotiline, Mirtazapine, Nefazodone, tricyclic antidepressants (e.g., Amitriptyline, Nortriptyline), appetite suppressants such as Diethylpropion, and attention deficit disorder medications like Atomoxetine and Methylphenidate. Other interacting drugs are Apraclonidine, bupropion, Buspirone, Carbamazepine, Cyclobenzaprine, deutetrabenazine, and dextromethorphan. Some blood pressure medications, like guanethidine, Methyldopa, and beta-blockers (e.g., Atenolol, Clonidine, rauwolfia alkaloids), also interact with this drug. Additionally, other MAO inhibitors (such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine), Metoclopramide, specific opioids like Fentanyl, Meperidine, methadone, tapentadol, Parkinson's medications (e.g., Entacapone, Levodopa, Tolcapone), and street drugs like LSD and mescaline can interact. Stimulants, including amphetamines, cocaine, dopamine, Epinephrine, Phenylalanine, Tetrabenazine, "triptan" migraine medications (e.g., Sumatriptan, Rizatriptan), Tramadol, Tyrosine, Tryptophan, and valbenazine are also included.

The risk of serotonin syndrome or toxicity is heightened if you use other drugs that increase serotonin levels. This includes street drugs like MDMA ("ecstasy"), St. John's wort, and certain antidepressants such as SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine). The likelihood of serotonin syndrome/toxicity increases when starting or increasing the dose of these medications.

Inform your doctor or pharmacist if you're using any of these drugs before, during, or within two weeks after taking phenelzine. If you have taken fluoxetine, you must wait at least five weeks before starting phenelzine. Discuss with your doctor the appropriate time to wait between starting or stopping these drugs and taking phenelzine.

Also, notify your doctor or pharmacist if you are using other products that may cause drowsiness, such as opioid pain or cough relievers (e.g., codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine).

Check the labels on all your medications, including allergy, cough-and-cold products, and diet pills, as they may contain dextromethorphan, decongestants, stimulants, or ingredients that cause drowsiness. Consult your pharmacist about the safe use of these products.

It's crucial to follow specific dietary restrictions to limit tyramine intake. Avoid consuming large amounts of Caffeine-containing beverages (coffee, tea, colas) or chocolate, as caffeine can amplify the medication’s side effects. Foods and drinks high in tyramine should be avoided while taking this medication and for at least two weeks after discontinuation.

High-tyramine foods include aged cheeses (e.g., cheddar, camembert, emmenthaler), cured or processed meats and fish (e.g., bacon, hot dogs, salami), banana peel, stored beef/chicken liver, bouillon cubes, concentrated yeast extracts, fermented beans, kimchi, overripe fruits, packaged soups, red wine, sauerkraut, soy products, tap beer, and vermouth.

Moderate-to-low tyramine foods include alcohol-free beer, avocados, bananas, bottled beer, chocolate, coffee, cultured dairy products (e.g., yogurt, sour cream), distilled spirits, eggplant, canned figs, green beans, pate, peanuts, port wine, raisins, raspberries, red plums, spinach, tomatoes, and white wine.

Immediately inform your doctor or pharmacist if you experience high blood pressure symptoms, such as a fast or slow heartbeat, vomiting, sweating, headache, chest pain, sudden vision changes, one-sided weakness, or difficulty speaking. For more information and dietary recommendations, consult your healthcare professionals, including your doctor, pharmacist, or dietician.