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Antidepressant medications are prescribed to manage conditions like depression and other mental health disorders. They can be beneficial in preventing suicidal thoughts and attempts. However, it is crucial to be aware that a small number of individuals, particularly those under the age of 25, may experience an increase in depression symptoms, changes in mental health, or suicidal thoughts and behaviors when using these medications. Discussing the risks and benefits with a doctor is essential, especially for younger individuals, even if the prescription is not for a mental health condition.

• Report any signs of worsening depression or psychiatric conditions to a healthcare provider immediately.
• Be vigilant about any unusual changes in behavior, such as potential suicidal thoughts or attempts, increased anxiety, panic attacks, difficulty sleeping, irritability, anger, impulsive behavior, severe restlessness, or rapid speech.
• Pay close attention to these symptoms when starting a new antidepressant or adjusting the dosage.

When taking this medication, you may experience some mild side effects such as nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating. These are generally not serious, but if they persist or worsen, it is important to inform your healthcare provider. Dizziness or lightheadedness, especially when starting or increasing the dosage, can also occur. To minimize the risk, rise slowly from sitting or lying positions.

Monitoring your blood pressure is important, as this medication can cause an increase. If you notice elevated readings, consult your healthcare provider. Serious side effects, while less common, require immediate medical attention. These include confusion, easy bruising or bleeding, decreased sexual interest or ability, muscle cramps, weakness, tremor, difficulty urinating, and signs of liver issues such as persistent nausea, abdominal pain, vomiting, yellowing of the skin or eyes, and dark urine.

In rare cases, the medication may lead to severe side effects, including black stools, vomit resembling coffee grounds, seizures, eye pain or redness, widened pupils, and vision changes. A serious condition called serotonin syndrome may occur, especially if combined with other serotonin-increasing drugs. Symptoms include rapid heartbeat, hallucinations, coordination loss, severe dizziness, nausea, twitching, unexplained fever, and agitation.

Allergic reactions to this medication are rare but serious. Seek immediate medical help if you experience rash, itching, swelling of the face, tongue, or throat, severe dizziness, difficulty breathing, skin blisters, or mouth sores. This summary does not cover all possible side effects. If you notice other unusual effects, contact your healthcare provider for advice.

Some medications may interact with this drug, including those that can lead to bleeding or bruising. These include antiplatelet drugs like Clopidogrel, NSAIDs like Ibuprofen and Naproxen, and blood thinners such as Dabigatran and Warfarin. Additionally, certain medications can influence how duloxetine is removed from your body, potentially impacting its effectiveness. Examples are Cimetidine, viloxazine, and certain quinolone antibiotics like Ciprofloxacin and enoxacin.

This drug may also slow the elimination of other medications from your body, which can alter their effects. Affected drugs include antiarrhythmics such as Propafenone, Flecainide, and quinidine, antipsychotics like Thioridazine, and tricyclic antidepressants such as Desipramine and imipramine.

Avoid using MAO inhibitors (such as isocarboxazid, Linezolid, and others) with this medication, as it could lead to a severe, possibly fatal, interaction. Most MAO inhibitors should not be taken for two weeks before and at least five days after using this medication. Consult your doctor for guidance on when to start or stop taking these drugs.

The risk of serotonin syndrome or toxicity rises if you take other medications that increase serotonin levels. This includes street drugs like MDMA, St. John's wort, certain antidepressants including SSRIs like Fluoxetine and paroxetine, other SNRIs like desvenlafaxine and Venlafaxine, and Tryptophan. The risk may be higher when you begin or increase the dose of these medications.

Inform your doctor or pharmacist if you use other products that cause drowsiness, including alcohol, marijuana, antihistamines like Cetirizine and diphenhydramine, sleep or anxiety medications such as Alprazolam, Diazepam, and Zolpidem, muscle relaxants, and opioid pain relievers like codeine. Check all your medicine labels for ingredients that cause drowsiness, and consult your pharmacist for safe use.

Aspirin can heighten bleeding risk when combined with this medication. However, if your doctor has advised you to take low-dose aspirin to prevent a heart attack or stroke (usually 81-162 milligrams daily), continue taking it unless your doctor instructs otherwise.