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Duloxetine

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generic Cymbalta, Drizalma Sprinkle

Duloxetine, marketed as Cymbalta, is a medication prescribed to manage depression, anxiety, and various chronic pain conditions. This includes nerve pain from diabetes (diabetic neuropathy), fibromyalgia, and long-term pain affecting the muscles, bones, joints, or tendons. Duloxetine functions as a serotonin-norepinephrine reuptake inhibitor (SNRI), aiming to enhance mood and alleviate pain by increasing the levels of serotonin and norepinephrine in the brain. The typical dosage involves taking a capsule once daily, though some individuals with depression might require it twice daily. Common side effects can include nausea, headache, and dry mouth. If discontinuation is necessary, a gradual dose reduction under medical supervision is advised to mitigate withdrawal symptoms such as anxiety and sleep disturbances. Always consult with your healthcare provider before starting or stopping this medication to ensure it is safe and appropriate for your condition.
Our coupons are free to use. Before paying, show the pharmacist your Duloxetine savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Duloxetine prices will update based on your prescription needs. Above our Duloxetine coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Duloxetine at the lowest price with our prescription discount card.

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20MG, Duloxetine (30 Capsule Delayed Release Particles)

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CVS

$19.23

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Walmart

$5.61

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Rite Aid

$6.67

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Albertsons

$11.87

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Walgreens

$52.59

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Duloxetine savings card

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CVS

$19.23

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Duloxetine dosage forms

The average cost for 30 Capsule Delayed Release Particles of Duloxetine (generic Cymbalta, Drizalma Sprinkle) at 20MG is $5.61 with a free coupon. This is 5.76% off the average retail price of $97.43
DosageQuantityPrice fromPer unit
20MG30 Capsule Delayed Release Particles$5.61$0.19
30MG30 Capsule Delayed Release Particles$5.38$0.18
60MG30 Capsule Delayed Release Particles$5.97$0.2
40MG30 Capsule Delayed Release Particles$32.46$1.08

Duloxetine Warnings

Antidepressant medications, such as Duloxetine (Cymbalta), are effective for treating depression and various mental or mood disorders. While these medications can prevent suicidal thoughts and provide significant benefits, they also carry potential risks. Below is important safety and warning information to consider:

  • Risk of Suicidal Thoughts and Behavior: Especially in individuals 24 years or younger and those with a history of depression or mental health conditions, Duloxetine may increase the risk of worsening depression or suicidal thoughts. Monitor for any new or worsening symptoms, especially when initiating treatment or modifying dosage. Immediate consultation with a healthcare professional (HCP) is advised if such changes occur.

  • Liver Damage: Rare but serious liver issues have been reported. Symptoms like stomach pain, nausea, vomiting, leg swelling, and jaundice require urgent medical attention. Individuals with a history of liver problems or those consuming alcohol are at higher risk.

  • Blood Pressure Changes and Fall Risk: Regular blood pressure monitoring is essential as Duloxetine can cause fluctuations. The risk is heightened in older adults, those with balance issues, or individuals taking more than 60 mg daily or other blood pressure-lowering drugs.

  • Serotonin Syndrome: This potentially life-threatening condition occurs with excessive serotonin in the brain, especially when combined with other serotonergic drugs. Seek immediate medical help if symptoms like a fast heart rate, sweating, muscle stiffness, high fever, or confusion arise.

  • Increased Bleeding Risk: Duloxetine may elevate bleeding risk, particularly if combined with aspirin, NSAIDs, or blood thinners. Be alert for unexplained bruising, black stools, pink/red urine, or unusual nose/gum bleeding, and inform your HCP promptly.

  • Severe Skin Reactions: Rare severe skin reactions can occur. Urgent medical attention is necessary if painful blisters, peeling rash, or sores develop.

  • Withdrawal Symptoms: Abrupt discontinuation can trigger withdrawal effects such as nausea, anxiety, confusion, trouble sleeping, and dizziness. Consult your HCP for a gradual tapering plan.

  • Mania: In individuals with a personal or family history of bipolar disorder, Duloxetine may provoke manic episodes. Report any unusual behavioral changes to your HCP immediately.

  • Low Sodium Levels: This condition may develop, particularly in older adults or those with SIADH, taking diuretics, or experiencing dehydration. Symptoms like headaches, confusion, or balance issues warrant contacting your HCP.

  • Sexual Problems: Some adults may experience sexual dysfunction, including erectile issues and decreased libido. Discuss any distressing sexual side effects with your HCP.

Contraindications: Duloxetine should not be used if you are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) within the last 14 days, or if undergoing treatment with linezolid (Zyvox) or methylene blue. Always consult your healthcare provider before starting this medication if these conditions apply to you.

Duloxetine Side Effects

Common side effects:

  • nausea
  • dry mouth
  • constipation
  • loss of appetite
  • tiredness
  • drowsiness
  • dizziness
  • increased sweating
  • headaches
  • trouble sleeping
  • diarrhea
  • stomach pain

Less common but important to monitor:

  • blurry vision
  • abnormal heartbeat
  • tremors
  • vomiting
  • low sex drive
  • yawning
  • changes in weight

Serious side effects:

  • suicidal thoughts or behaviors
  • significant liver damage
  • symptoms of serotonin syndrome
  • severe bleeding or bruising
  • low sodium levels
  • severe skin reactions
  • seizures
  • confusion
  • hallucinations
  • unexplained fever
  • severe dizziness
  • fast heartbeat
  • very serious allergic reaction
  • rash
  • itching/swelling (especially of the face, tongue, or throat)
  • trouble breathing
  • skin blisters
  • mouth sores

Duloxetine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Duloxetine FAQs
What does duloxetine do for a person?

Duloxetine is a medication that primarily helps in managing major depressive disorder, generalized anxiety disorder, and certain types of chronic pain, such as fibromyalgia and diabetic neuropathy. It works by affecting the balance of neurotransmitters in the brain, which can help improve mood, relieve anxiety, and reduce pain perception.

Duloxetine and gabapentin are not the same. They are different medications used to treat different conditions. Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) commonly used to treat depression, anxiety, and certain types of chronic pain. Gabapentin, on the other hand, is an anticonvulsant often used to treat nerve pain and seizures.

Weight changes can occur with duloxetine, but they vary among individuals. Some people may experience weight gain, while others might lose weight or see no change at all. It's important for patients to monitor their weight and discuss any significant changes with their healthcare provider.

Duloxetine is not a narcotic. It is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI) and is commonly used to treat conditions such as depression, anxiety, and certain types of chronic pain.

Xanax (alprazolam) and duloxetine are medications used to treat different conditions and belong to different drug classes. Xanax is a benzodiazepine primarily used for the management of anxiety disorders and panic disorders. It works by enhancing the effects of a neurotransmitter called GABA in the brain, which has a calming effect.Duloxetine, on the other hand, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder, generalized anxiety disorder, and certain types of chronic pain, such as fibromyalgia and neuropathic pain. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood and reduce pain perception.In summary, the main differences lie in their drug classes, mechanisms of action, and the conditions they are used to treat.