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This document outlines essential safety and warning information about the use of potassium iodide. Please read carefully, and consult your healthcare provider if you have any questions or concerns.

• Allergic Reactions: Potassium iodide can cause serious allergic reactions, primarily due to its iodide content. Be aware of symptoms such as swelling, difficulty breathing or swallowing, skin rashes, or fever accompanied by joint pain. If you experience any of these, seek medical attention immediately. Risk: Allergy to iodides.

• Thyroid Issues: This medication may impact thyroid gland function. While short-term use (typically one day) is generally safe, prolonged use can increase the risk of thyroid complications. If you are pregnant, breastfeeding, or caring for an infant under one month old, inform your healthcare provider. Risk factors include a history of hyperthyroidism, extended use of potassium iodide, younger children, newborns, and individuals who are pregnant or breastfeeding.

• Contraindications: Do not use potassium iodide if you have any of the following conditions, as they pose serious health risks:

  • Allergy to iodides
  • Nodular thyroid disease with associated heart disease
  • Hypocomplementemic vasculitis
  • Dermatitis herpetiformis

Always consult with your healthcare provider to ensure potassium iodide is safe for your use, especially if you have any pre-existing conditions or are part of a vulnerable population.

Common side effects:

• Swelling of the salivary glands
• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Fever
• Headache
• Metallic taste

Less common but important to monitor:

• Chest pain
• Changes in heart rate

Serious side effects:

• Severe allergic reaction characterized by difficulty breathing or swallowing
• Skin rash
• Fever with joint pain
• Swelling in the face, hands, or feet

Potassium iodide (KI) is a medication commonly used to protect the thyroid gland from radioactive iodine exposure and to treat certain thyroid conditions. However, it can interact with various medications and medical conditions, potentially leading to adverse effects.

Drug Interactions:

When taken with certain medications, potassium iodide may increase the risk of elevated potassium levels in the blood (hyperkalemia). This risk is particularly notable with:

• Angiotensin-Converting Enzyme (ACE) Inhibitors: Medications like Captopril and Lisinopril.

• Angiotensin II Receptor Blockers (ARBs): Such as Losartan and Valsartan.

• Potassium-Sparing Diuretics: Including Amiloride, Spironolactone, and Triamterene.

• Certain Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Such as Ibuprofen and Indomethacin.

Combining potassium iodide with these medications requires careful monitoring of potassium levels to prevent complications.

Additionally, concurrent use of potassium iodide with antithyroid agents like Methimazole or Propylthiouracil can increase the likelihood of hypothyroidism. Therefore, such combinations should be approached with caution.

Disease Interactions:

Certain medical conditions can be exacerbated by potassium iodide:

• Hyperthyroidism: In individuals with an overactive thyroid, potassium iodide can further stimulate thyroid activity, potentially worsening the condition.

• Heart Disease: Elevated potassium levels can affect heart rhythm, posing risks for those with existing heart conditions.

• Dermatitis Herpetiformis and Vasculitis: These skin conditions may be aggravated by iodine intake, leading to increased symptoms.

Before starting potassium iodide, it's essential to inform your healthcare provider about all medications you're taking and any existing health conditions. This ensures that potential interactions are identified and managed appropriately, safeguarding your health.