Protamine Coupons & Savings Card – Discount Prices from $37.81
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1GM, Protamine (1 Bottle)
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CVS
$71.84
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$37.81
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$48.80
COUPON PRICEProtamine savings card
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$37.81
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Protamine dosage forms
| Dosage | Quantity | Price from | Per unit |
|---|---|---|---|
| 1GM | 1 Bottle | $37.81 | $37.81 |
Protamine Warnings
This document outlines essential safety and warning information related to the use of protamine. Please read the following points carefully and discuss any concerns with your healthcare provider.
Severe Heart Problems: Though uncommon, protamine can lead to serious heart issues, such as low blood pressure, slow heart rate, sudden collapse, and fluid accumulation in the lungs. Healthcare providers will closely monitor your vital signs before, during, and after administration. Increased risk is associated with rapid administration, high doses, repeated dosing, and concurrent use of other protamine-containing medications.
Serious Allergic Reactions: There is a possibility of severe allergic reactions to protamine, including potentially life-threatening anaphylaxis. Indicators of such reactions include dizziness, nausea, a choking sensation, difficulty breathing, and swelling around the eyes, lips, or tongue. Your healthcare provider will observe for these symptoms while you receive protamine to ensure timely intervention.
Please consult with your healthcare provider to ensure safe usage of protamine, especially if you are at an increased risk due to any of the factors mentioned above.
Protamine Side Effects
Common side effects:
- Low blood pressure
- Slow heart rate
Less common but important to monitor:
- Back pain
- Shortness of breath
- Nausea
- Vomiting
- Flushing
- Lack of energy
Serious side effects:
- Serious allergic reactions
- Difficulty breathing
- Tightness in the throat
- Hives
- Fast heartbeat
- Dizziness
- Lightheadedness
- Swelling of the face or tongue
Protamine Interactions
Protamine is primarily used to counteract the effects of heparin, a common anticoagulant. However, it can interact with various other medications, potentially altering their effectiveness or increasing the risk of adverse effects. Notable interactions include:
Hormonal Contraceptives: Protamine may reduce the effectiveness of birth control pills, necessitating the use of alternative contraceptive methods.
Cyclosporine: Concurrent use with protamine is contraindicated due to a significantly increased risk of liver toxicity.
Rifampin: This antibiotic may diminish the effectiveness of protamine.
Warfarin: Co-administration requires careful monitoring, as protamine can influence warfarin's anticoagulant effects.
Insulin: Protamine can affect insulin levels, so close monitoring is essential when these are used together.
Other Anticoagulants: Using protamine alongside other blood thinners may elevate the risk of bleeding.
Certain Antibiotics: Some antibiotics can interact with protamine, potentially affecting its efficacy.
Given these potential interactions, it's crucial to inform your healthcare provider about all medications, supplements, or herbal products you are currently taking before starting protamine therapy. This ensures safe and effective use of the medication.
Why does protamine reverse heparin?
Protamine reverses heparin because it is a positively charged protein that binds to the negatively charged heparin, forming a stable complex. This interaction neutralizes the anticoagulant effect of heparin, effectively reversing its action.
What are the side effects of protamine?
Protamine can cause several side effects. Common side effects include hypotension (low blood pressure), bradycardia (slow heart rate), and flushing. It may also cause allergic reactions, which can range from mild to severe, including anaphylaxis. Other potential side effects include nausea, vomiting, and back pain. In some cases, it can lead to pulmonary hypertension or bleeding complications. It is important for patients to be monitored closely when receiving protamine, especially if they have a history of fish allergies or previous reactions to protamine.
What is the difference between protamine sulfate and vitamin K?
Protamine sulfate and vitamin K are both used to reverse the effects of certain anticoagulants, but they work in different ways and are used for different medications. Protamine sulfate is used to reverse the effects of heparin, an anticoagulant that prevents blood clots. It works by binding to heparin and neutralizing its anticoagulant activity.Vitamin K, on the other hand, is used to reverse the effects of warfarin, another anticoagulant. Warfarin works by inhibiting vitamin K-dependent clotting factors, and administering vitamin K helps restore these factors, thereby reversing the anticoagulation effect.In summary, protamine sulfate is used for heparin reversal, while vitamin K is used for warfarin reversal.
What does protamine do to the body?
Protamine is primarily used to reverse the effects of heparin, an anticoagulant medication. When administered, protamine binds to heparin, neutralizing its anticoagulant properties and thereby reducing the risk of bleeding. This action is particularly useful during surgical procedures or when there is a need to quickly counteract heparin's effects.
What happens if you give protamine without heparin?
Administering protamine without prior heparin exposure can lead to adverse effects, as protamine itself has anticoagulant properties. In the absence of heparin, protamine can potentially cause bleeding due to its anticoagulant effect. Additionally, protamine administration can result in hypotension, bradycardia, and allergic reactions, especially in individuals with a history of fish allergies or previous exposure to protamine. It is important to use protamine only when indicated to reverse heparin's effects.