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The safety and warning information provided below highlights crucial details regarding the use of this medication. It is essential to carefully consider these points and discuss any concerns with your healthcare provider.

• Increased Mortality in Elderly with Dementia-related Psychosis: Individuals aged 65 and older with dementia-related psychosis should not be treated with prochlorperazine as it may increase the risk of death. Notify your healthcare provider if you or a loved one has dementia before beginning treatment.

• Tardive Dyskinesia: Prochlorperazine may lead to uncontrolled, possibly permanent muscle movements, particularly affecting the tongue, face, and limbs. To minimize risk, use the lowest effective dose for the shortest duration. Discontinue use and consult your healthcare provider immediately if you notice involuntary movements.

• Other Uncontrolled Muscle Movements: The medication may cause dystonia, Parkinsonian symptoms, and restlessness. Symptoms such as muscle stiffness, tremors, or pacing may appear within the first 24 to 48 hours and typically resolve upon stopping the medication. Consult your healthcare provider if these symptoms occur.

• Neuroleptic Malignant Syndrome (NMS): A rare but potentially fatal condition that can occur with prochlorperazine usage. Symptoms include high fever, muscle stiffness, and rapid heartbeat. Seek medical attention immediately if these occur. Exercise caution when using this medication with other antipsychotics or lithium.

• Masking Serious Health Issues: Prochlorperazine may alleviate nausea and vomiting, potentially masking more serious conditions like drug overdose or poisoning. It may also cause side effects that resemble other illnesses. Avoid use in children and teens who may have Reye's syndrome.

• Increased Infection Risk: The medication can lower white blood cell counts, leading to serious infections. Regular blood tests may be necessary. Alert your healthcare provider if you experience fever, weakness, or sore throat.

• Fall Risk: Prochlorperazine can cause low blood pressure, leading to dizziness or falls. Stand or sit slowly and consult your provider if dizziness persists.

• Liver Damage: Serious liver issues may arise. Contact your healthcare provider if you experience symptoms like jaundice, fever, or dark urine.

• Seizure Risk: Individuals with a history of seizures should consult their provider as medication adjustments might be needed. Use caution in activities where sudden unconsciousness could be harmful.

• Elevated Prolactin Levels: The medication can increase prolactin hormone levels, causing symptoms such as breast changes or menstrual irregularities. Discuss these symptoms with your healthcare provider.

• Temperature Regulation: Prochlorperazine may impair your body's ability to regulate temperature. Take care in hot environments.

Contraindications: Do not use this medication if you are in a coma, consume large amounts of alcohol, take high doses of sedative medications, are undergoing surgery (for children), or if the patient is a child under 2 years old or under 20 pounds. Always consult your healthcare provider for further guidance.

Common side effects:

• Drowsiness
• Dizziness
• Absent menstrual periods
• Blurry vision
• Low blood pressure

Less common but important to monitor:

• Low white blood cell count
• Liver problems

Serious side effects:

• Uncontrolled muscle movements (tardive dyskinesia)
• Neuroleptic malignant syndrome (nms)
• Seizures