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The drug methylphenidate carries risks of serious heart and blood pressure issues if misused or abused. It is also habit-forming, so individuals with mental health disorders or a history of substance abuse should use it with caution. Here are important safety considerations:

• Personal and Family History: Inform your healthcare provider if you or your family have a history of substance use disorders, including drug or alcohol misuse.
• Adherence to Prescription: Use this medication strictly as prescribed. Do not increase your dose, take it more frequently, or alter the duration or method of administration. Doing so may lead to reduced effectiveness, dependence, or abnormal thoughts and behaviors.
• Monitoring: After stopping the medication, especially if used at high doses or for a prolonged period, your doctor may need to monitor you to ensure safety.

Always follow your healthcare provider's instructions and report any unusual symptoms immediately.

When taking this medication, you might experience common side effects such as nervousness, trouble sleeping, loss of appetite, weight loss, dizziness, nausea, vomiting, or headache. These are generally manageable, but if they persist or worsen, it's important to seek advice from your healthcare provider. Additionally, this medication can sometimes increase blood pressure, so regular monitoring is recommended to ensure it remains within a healthy range.

Be vigilant for serious side effects, which require immediate medical attention. These include signs of blood flow issues in fingers or toes, such as coldness, numbness, or unusual wounds. Also, watch for fast or irregular heartbeat, changes in mood or behavior, uncontrolled muscle movements, and vision changes. In very rare cases, males may experience a painful or prolonged erection lasting more than four hours, necessitating urgent medical intervention to prevent long-term complications.

Serious allergic reactions are uncommon but serious. If you notice symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing, seek emergency medical help. While this overview covers key side effects, it's not exhaustive. Should you observe any other unusual symptoms, contact your healthcare provider promptly for guidance.

Avoid combining this medication with MAO inhibitors, as this can lead to a severe and potentially life-threatening interaction. MAO inhibitors include drugs like isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine. It is important not to take these inhibitors during treatment with this medication, and most should also be avoided for two weeks prior to starting this medication. Consult your doctor about when to begin or discontinue use.

Methylphenidate closely resembles dexmethylphenidate, so do not use any medications containing dexmethylphenidate while taking methylphenidate.

This drug may affect certain medical or laboratory tests, such as those for Parkinson's disease, resulting in inaccurate outcomes. Ensure that all healthcare providers and laboratory staff are aware that you are using this medication.