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It is crucial to be aware of the safety information and warnings associated with the use of methylphenidate ER to prevent potential risks and ensure proper usage. Below are important details to consider:

• Misuse and Dependence: Methylphenidate ER carries a risk of misuse and dependence. Misusing the medication by taking it differently from the prescribed method can lead to serious side effects, such as rapid heart rate, increased blood pressure, aggressive behavior, and even self-harming thoughts. Individuals with a history of substance or alcohol use disorders should use it cautiously. Do not exceed the prescribed dose or suddenly stop taking the medication without consulting your doctor.

• Serious Heart Issues: There have been instances of sudden death, stroke, and heart attack associated with methylphenidate ER, even at regular doses. The medication can increase both blood pressure and heart rate. Individuals with a history of heart problems should inform their healthcare provider prior to starting treatment to ensure safety. Seek medical advice if you experience unexplained fainting, chest pain during physical activity, or an irregular heartbeat.

• Behavioral and Mental Changes: Use of methylphenidate ER may induce mental health issues, including hallucinations, erratic thinking, or mania. These symptoms can occur regardless of previous mood-related problems. Consult your healthcare provider if you notice such symptoms.

• Prolonged and Painful Erection: Rarely, methylphenidate ER can cause prolonged and painful erections, which may require medical intervention. If an erection lasts longer than 4 hours, discontinue the medication and seek immediate medical attention.

• Blood Circulation Issues: Some users may experience Raynaud's phenomenon, characterized by poor blood flow, leading to pale, cold, numb, or painful fingers and toes. Notify your healthcare provider if you observe these symptoms, as dosage adjustments might be necessary.

• Growth Delay in Children: Stimulants like methylphenidate ER have been linked to temporary growth delays in children. Healthcare providers will monitor growth closely and may adjust treatment if needed.

• Serotonin Syndrome: This rare but serious condition can occur when methylphenidate ER is combined with other serotonin-affecting medications, such as certain antidepressants and migraine drugs. Be observant for symptoms like fast heart rate, sweating, muscle stiffness, high fever, and confusion, and seek immediate medical help if they appear.

• Drug Interactions: Methylphenidate ER can interact with numerous medications, especially blood pressure drugs and MAOIs, potentially leading to dangerously high blood pressure. Discuss all medications and supplements with your healthcare provider to avoid adverse interactions.

Contraindications: Do not use methylphenidate ER if you have severe allergies to its components, have taken MAOIs in the past 14 days, or have certain sugar digestion issues. The Relexxi brand is not recommended for those with marked anxiety, tension, glaucoma, motor tics, or a family history of Tourette syndrome.

For any concerns or further clarification, always consult your healthcare provider.

This medication may lead to several side effects, which vary in frequency and severity. Common side effects include nervousness, trouble sleeping, loss of appetite, weight loss, headache, stomach pain, and dizziness. These are usually mild but should be discussed with a healthcare provider if they persist or worsen. Some individuals may also experience dry mouth, nausea, vomiting, anxiety, and irritability.

It's important to monitor blood pressure regularly while using this medication, as it may cause an increase. If you notice symptoms such as a racing heart or excessive sweating, contact your healthcare provider. Serious side effects are rare but require immediate medical attention. These include signs of heart problems, such as chest pain or a fast heart rate, and brain-related issues like seizures or stroke symptoms. Mental health changes, including mood swings or thoughts of suicide, should be addressed urgently.

In rare instances, males may experience a prolonged or painful erection lasting more than four hours, requiring prompt medical intervention. Allergic reactions, although uncommon, are serious and include symptoms like rash, hives, or difficulty breathing. If any of these occur, seek medical help immediately. Always report any unusual effects to your healthcare provider, as this is not an exhaustive list of side effects.

When taking Methylphenidate, be aware of potential drug interactions. It is crucial to avoid using this medication with MAO inhibitors such as isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine. Combining these can lead to a serious, possibly life-threatening interaction. You should also not take most MAO inhibitors for two weeks before starting Methylphenidate. Consult your doctor for guidance on when to begin or cease these medications.

Additionally, do not use Methylphenidate in conjunction with Dexmethylphenidate, as they are very similar and could result in adverse effects.

Inform your healthcare providers about all medications and supplements you are taking, including prescribed, over-the-counter, vitamins, and herbal supplements, as Methylphenidate ER may cause interactions.

Some medications, like furazolidone, iproniazid, and nialamide, should not be used with Methylphenidate. In some cases, your doctor might adjust dosages if you are prescribed medications such as amifampridine, bupropion, or Risperidone, which may not be ideal to use together but could be necessary for treatment.

Finally, Methylphenidate can interfere with certain medical tests, potentially causing false results, so ensure all medical professionals involved in your care are aware that you are using this medication.