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When using methylphenidate, it is crucial to be aware of the associated safety concerns and warnings. This medication requires careful management due to its potential risks and interactions with other substances. Below are key points to consider:

• Risk of Misuse and Dependence: Methylphenidate can be habit-forming. Misuse, such as using it in a way not prescribed, can lead to serious side effects including rapid heartbeat, high blood pressure, and aggressive behavior. Individuals with a history of substance or alcohol use disorder should exercise caution. Avoid increasing the dose or abruptly stopping the medication without consulting your healthcare provider.

• Heart Complications: There is a risk of serious heart issues, including sudden death, stroke, and heart attack, even at usual doses. Methylphenidate may increase blood pressure and heart rate. Notify your doctor if you have a history of heart problems before starting this medication. Seek immediate medical attention if you experience symptoms like fainting, chest pain, or irregular heartbeat.

• Mental Health Changes: Methylphenidate may cause or worsen mental health issues such as hallucinations, abnormal thinking, and mania. These can occur even in those without a prior history of such conditions. If you notice changes in mood or behavior, contact your healthcare provider immediately.

• Prolonged and Painful Erection: Rarely, methylphenidate can cause prolonged and painful erections, which may require medical intervention. Discontinue the medication and seek urgent medical care if an erection lasts more than four hours.

• Blood Circulation Issues: The medication may lead to Raynaud's phenomenon, causing reduced blood flow to fingers and toes, resulting in pale, cold, or numb skin. Inform your doctor if you experience these symptoms, as a dosage adjustment may be necessary.

• Growth Impact in Children: Children using methylphenidate may experience slowed growth in height and weight. Healthcare providers will monitor growth closely and may adjust treatment if necessary.

• Serotonin Syndrome Risk: When combined with other medications affecting serotonin levels, such as certain antidepressants, there is a risk of serotonin syndrome, a potentially life-threatening condition. Symptoms include rapid heartbeat, high fever, and confusion. Immediate medical attention is required if these occur.

• Drug Interactions: Methylphenidate can interact with many medications, particularly those affecting blood pressure and monoamine oxidase inhibitors (MAOIs), which can lead to dangerous increases in blood pressure. Discuss all medications and supplements with your healthcare provider.

• Contraindications: Avoid using methylphenidate if you have severe allergies to it, have used MAOIs in the last 14 days, or have certain digestive disorders. The Relexxi brand is contraindicated in cases of glaucoma, motor tics, or a family history of Tourette syndrome.

Always consult your healthcare provider for personalized advice and before making any changes to your medication regimen.

When taking Methylphenidate Er, it is important to inform your doctor and pharmacist about all the medications and supplements you are using, including both prescription and over-the-counter drugs, vitamins, and herbal products.

Interactions to Avoid:

• Avoid using Methylphenidate ER with MAO inhibitors such as Isocarboxazid, Linezolid, Methylene Blue, Moclobemide, Phenelzine, Procarbazine, Rasagiline, Safinamide, Selegiline, and Tranylcypromine. Concurrent use can lead to serious and potentially fatal interactions. It is advised to stop using MAO inhibitors two weeks before beginning treatment with Methylphenidate ER. Consult your doctor for guidance on when to start or stop medications.

Potential Cautious Use:

• Some medications, like Amifampridine, Bupropion, Desflurane, and others, may not typically be recommended with Methylphenidate ER unless necessary. Your doctor might adjust doses or the frequency of use if both medications are needed.

Increased Side Effects:

• The use of Methylphenidate ER with Carbamazepine may heighten certain side effects, though it might be required for optimal treatment. Your doctor will determine the best course of action for using these medications together.

Additionally, note that Methylphenidate is very similar to Dexmethylphenidate, so avoid using them simultaneously. Also, Methylphenidate ER might affect certain medical tests, such as brain scans for Parkinson's disease, so ensure your healthcare providers are aware you are taking this medication.