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The following safety information highlights important risks and precautions associated with the use of amphetamine medications such as Adderall. It is crucial to review these points carefully and discuss any concerns with your healthcare provider.

• Misuse and Addiction: Amphetamine medications are classified as schedule II controlled substances due to their high potential for misuse and addiction. Misusing these medications can lead to serious side effects, including rapid heart rate, elevated blood pressure, aggressive behavior, and even self-harm thoughts. Always use amphetamines as prescribed and consult your psychiatrist if you are concerned about misuse or addiction, especially if there's a history of substance or alcohol use disorder.

• Dependence and Withdrawal: Long-term use can lead to physical dependence, requiring the drug for normal functioning. Abruptly stopping or reducing the dose can cause withdrawal symptoms such as irritability, nightmares, and sleep disturbances. Always follow your psychiatrist’s instructions regarding dosage changes.

• Serious Heart Issues: There is a risk of sudden death, stroke, or heart attack in individuals with existing heart conditions taking amphetamines. This medication can also increase blood pressure and heart rate. Inform your healthcare provider about any heart issues before starting treatment. Seek immediate medical attention if you experience fainting, chest pain during physical activity, or irregular heartbeat.

• Mental Health Concerns: Use of amphetamines may cause or exacerbate mental health issues, including hallucinations, aggressive behavior, and unclear thinking. Report any mood or behavior changes to your psychiatrist immediately, as you may need to stop the medication. This risk is higher for those with a history of psychotic episodes or mood disorders.

• Growth in Children: In children, amphetamines may slow growth in height and weight. Regular monitoring by a healthcare provider is recommended, and medication adjustments may be necessary if growth concerns arise.

• Seizures: Although infrequent, amphetamines can increase the likelihood of seizures, particularly in those with a history of seizures. Seek emergency medical help if a seizure occurs and expect to discontinue the medication.

• Blood Circulation Problems: Amphetamines can cause circulation issues like Raynaud's phenomenon, leading to numbness or pain in extremities. Inform your physician if you experience these symptoms, as dosage adjustments may be required.

• Serotonin Syndrome: This rare but serious condition can occur when amphetamines are combined with other serotonin-increasing medications. Symptoms include rapid heart rate, muscle spasms, and confusion. Immediate medical attention is necessary if these symptoms develop.

• Drug Interactions: Amphetamines can interact with various medications, potentially diminishing the effectiveness of blood pressure drugs or increasing serotonin syndrome risk when combined with certain antidepressants and MAOIs. Always inform your healthcare provider about all medications and supplements you are taking.

• Contraindications: Do not use amphetamine medications if you have a severe allergy to its components or if you have taken MAOIs, linezolid, or methylene blue within the past 14 days.

For any concerns or questions regarding amphetamine use, it is essential to maintain open communication with your healthcare team.

Common side effects:

• upset stomach
• loss of appetite
• weight loss
• dry mouth
• nervousness
• headache
• dizziness
• diarrhea
• trouble sleeping

Less common but important to monitor:

• increase in blood pressure
• irregular or fast heartbeat
• blurred vision
• constipation
• changes in sexual desire or ability
• mood changes (such as agitation or nervousness)

Serious side effects:

• severe allergic reactions (such as rash, swelling, or breathing difficulties)
• severe headaches
• fainting
• chest pain
• seizures
• signs of serotonin syndrome (fast heartbeat, muscle stiffness, fever, or confusion)

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Serotonergic drugs (SSRIs such as Fluoxetine/paroxetine, SNRIs such as Duloxetine/Venlafaxine, St. John's wort, MDMA/ecstasy)
• Lisdexamfetamine

Interactions with low risk that usually do not require a change in therapy:

• Cough-and-cold products or diet aids