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It is important to be aware of the potential risks and necessary precautions associated with the use of Vyvanse (lisdexamfetamine), an amphetamine-type medication. This information is crucial for both patients and healthcare providers to ensure safe and effective use. Please review the following details carefully:

• Misuse and Dependence: Vyvanse can be habit-forming and has a risk of misuse, especially if not used as prescribed. Misuse can lead to severe side effects such as increased heart rate, elevated blood pressure, aggressive behavior, and harmful thoughts. Individuals with a history of substance or alcohol use disorder are at a higher risk. Dependency may develop with long-term use, leading to withdrawal symptoms if suddenly stopped. Consult your healthcare provider for guidance.

• Serious Cardiac Issues: There is a risk of serious heart-related events, including sudden death, stroke, and heart attack, even at recommended doses. Vyvanse can increase blood pressure and heart rate. Inform your healthcare provider of any pre-existing heart conditions before starting the medication, and report any symptoms like fainting, chest pain during physical activity, or irregular heartbeat immediately.

• Behavioral and Mental Health Changes: Some users may experience changes in behavior or mental health, such as hallucinations, unclear thinking, or mania. These symptoms can occur even in individuals without a prior history of such issues. If these symptoms arise, contact your healthcare provider immediately.

• Impact on Children's Growth: Vyvanse may slow growth in children, affecting both height and weight. Regular monitoring of the child's growth by a healthcare provider is recommended. If growth issues are suspected, treatment may need to be adjusted.

• Blood Circulation Issues: Vyvanse can cause problems with blood circulation, such as Raynaud's phenomenon, affecting the fingers and toes. Symptoms include color changes, coldness, numbness, or pain. Inform your provider if these occur.

• Serotonin Syndrome Risk: There is a rare but serious risk of serotonin syndrome, especially when combined with medications that affect serotonin levels, like certain antidepressants, MAOIs, and migraine medications. Symptoms include rapid heart rate, sweating, muscle stiffness, high fever, and confusion. Seek immediate medical attention if these occur.

• Drug Interactions: Vyvanse can interact with various medications, increasing the risk of side effects. Avoid using with MAOIs and certain heartburn products. Discuss all current medications with your healthcare provider to manage potential interactions effectively.

• Contraindications: Vyvanse should not be used if you have a severe allergy to amphetamines or if you are currently taking or have recently taken MAOIs or other specified medications. Consult your healthcare provider if these conditions apply.

By adhering to these guidelines and maintaining open communication with your healthcare provider, you can help ensure the safe use of Vyvanse.

Common side effects:

• nausea
• vomiting
• constipation
• dry mouth
• stomach or abdominal pain
• loss of appetite
• dizziness
• trouble sleeping
• sweating
• weight loss
• irritability
• restlessness

Less common but important to monitor:

• blurred vision
• fast or irregular heartbeat
• mood changes such as agitation or depression
• unusual changes in behavior
• uncontrolled movements
• muscle twitching
• signs of blood flow problems in the extremities
• prolonged erections
• changes in sexual interest
• rapid weight loss
• swelling of the ankles or feet
• extreme tiredness

Serious side effects:

• shortness of breath
• chest pain
• seizures
• sudden vision changes
• confusion
• serotonin syndrome
• allergic reactions such as rash, swelling, and breathing difficulties

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Drugs that increase serotonin (MDMA/ecstasy, St. John's wort, SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine)

Interactions with low risk that usually do not require a change in therapy:

• Products that raise heart rate or blood pressure (cough-and-cold products or diet aids)
• Medications containing amphetamine or dextroamphetamine