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Methylphenidate should be used with caution due to the risk of severe heart and blood pressure issues that can occur from misuse or abuse. It has the potential to be habit-forming, particularly for individuals with mental or mood disorders, or those with a history of substance misuse. It is crucial to inform your healthcare provider if you or your family have a history of substance use disorders before starting this medication.

• Do not increase the dosage, frequency, or duration of use beyond what is prescribed, as this can lead to reduced effectiveness, dependence, or unusual thoughts or behaviors.
• If you have been using this medication for a prolonged period or at high doses, your doctor may need to monitor you after discontinuation to ensure your safety.

While taking this medication, you might experience mild side effects like nervousness, difficulty sleeping, decreased appetite, weight loss, dizziness, nausea, vomiting, or headaches. These are common and often manageable, but if they persist or worsen, it's important to consult with a healthcare professional. Occasionally, you might notice an empty tablet shell in your stool; this is harmless as the drug has already been absorbed.

Be aware that this medication can raise blood pressure. Regular monitoring is advised, and any elevated results should be discussed with a healthcare provider. Serious side effects, though less common, require immediate attention. These include signs of circulation issues in fingers or toes, such as coldness or color changes, unusual wounds, irregular heartbeat, mood changes, uncontrolled muscle movements, and sudden vocal outbursts. If you experience sudden vision changes, fainting, seizures, or symptoms of a heart attack or stroke, seek emergency medical help.

Rarely, males, including young boys, may experience a painful or prolonged erection lasting over four hours. This is a medical emergency, and immediate attention is necessary to prevent lasting damage. Although severe allergic reactions are uncommon, symptoms like rash, swelling, severe dizziness, or breathing difficulties need urgent care. If you experience side effects not listed here, contact your healthcare provider for guidance.

Avoid using MAO inhibitors with this medication, as it can lead to a severe and potentially life-threatening interaction. MAO inhibitors include drugs like isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine. Do not take these during treatment with this medication, and most should be avoided for two weeks before starting this treatment. Consult your doctor for advice on when to begin or discontinue use of this medication.

Since Methylphenidate is closely related to Dexmethylphenidate, do not take medications containing dexmethylphenidate while using methylphenidate.

This medication might affect certain medical or lab tests, such as brain scans for Parkinson's disease, and could lead to incorrect results. Be sure that all lab technicians and healthcare providers are aware you are taking this drug.