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When taking this medication, you might experience common side effects such as dizziness, drowsiness, nausea, or vomiting. These are typically mild and temporary, but if they persist or worsen, it is important to consult with a healthcare professional for guidance. Many individuals use this medication without encountering severe side effects.

In rare cases, a very serious allergic reaction may occur. It is crucial to seek immediate medical attention if you experience symptoms such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. These symptoms can indicate a severe allergic response that requires prompt care.

While this summary covers some potential side effects, it is not exhaustive. If you notice any other unusual effects, it is advised to discuss them with a healthcare provider. Remember, the occurrence of serious side effects is uncommon, but being informed helps you stay prepared and ensures your safety while using the medication.

Using specific MAO inhibitors alongside this medication can result in a severe and potentially life-threatening interaction. It is important to avoid taking medications such as isocarboxazid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while on this treatment. Additionally, most MAO inhibitors should not be used for two weeks prior to starting this medication. Consult your doctor for guidance on when to begin or discontinue this treatment.

Another drug that may interact with this medication is rolapitant.

Furthermore, both prescription and over-the-counter forms of Guaifenesin and dextromethorphan are available. Ensure you are not using multiple products containing these ingredients simultaneously by checking all medication labels carefully.

Lastly, guaifenesin might affect certain laboratory tests, such as urine acidity measurements, potentially leading to incorrect results. Inform lab personnel and your healthcare providers that you are using this medication.