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When using this medication, it is crucial to be aware of potential interactions and safety precautions. The following guidelines are intended to help ensure safe use:

• Drug Interactions: This medication can cause a serious, and potentially fatal, interaction with certain MAO inhibitors. Avoid using isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine while on this medication. Additionally, most MAO inhibitors should not be taken for two weeks prior to starting this treatment. Consult your healthcare provider for advice on when to begin or discontinue use of this medication.

• Other Interactions: Rolapitant is another product that may interact with this drug. It is important to discuss all medications you are taking with your doctor to prevent adverse interactions.

• Product Duplication: Guaifenesin and dextromethorphan are ingredients found in both prescription and over-the-counter medications. Check all your medication labels to ensure you are not taking multiple products containing these substances.

• Laboratory Interference: Guaifenesin may affect certain laboratory tests (such as urine levels of specific acids), potentially leading to inaccurate results. Inform all healthcare professionals and laboratory staff that you are using this medication to prevent misinterpretation of test outcomes.

Adhering to these precautions can help minimize risks and ensure the medication is used safely and effectively.

Using specific MAO inhibitors alongside this medication can result in a severe and potentially life-threatening interaction. It is important to avoid taking medications such as isocarboxazid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while on this treatment. Additionally, most MAO inhibitors should not be used for two weeks prior to starting this medication. Consult your doctor for guidance on when to begin or discontinue this treatment.

Another drug that may interact with this medication is rolapitant.

Furthermore, both prescription and over-the-counter forms of Guaifenesin and dextromethorphan are available. Ensure you are not using multiple products containing these ingredients simultaneously by checking all medication labels carefully.

Lastly, guaifenesin might affect certain laboratory tests, such as urine acidity measurements, potentially leading to incorrect results. Inform lab personnel and your healthcare providers that you are using this medication.