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This document outlines essential safety information regarding the use of Sivextro (tedizolid). It is crucial to understand the associated risks and precautions to ensure safe use of this medication. If you have any questions or concerns, please consult your healthcare provider.

• Risk of C. difficile Infection: Sivextro (tedizolid) can alter the balance of bacteria in your gut, potentially leading to an overgrowth of Clostridioides difficile (C. diff). This can result in severe diarrhea. Symptoms of a C. diff infection to watch for include rapid heart rate, foul-smelling diarrhea, fever, nausea, and frequent bowel movements (up to 15 times per day). Seek immediate medical attention if you experience these symptoms to receive appropriate testing and treatment.

• Drug-Resistant Bacteria: It is essential to take Sivextro (tedizolid) exactly as prescribed. Deviating from the prescribed duration or using it for non-intended illnesses increases the risk of developing antibiotic-resistant infections. Such infections can be severe and may pose significant treatment challenges.

Please adhere to these guidelines to mitigate risks and ensure the effectiveness of your treatment. Always follow your healthcare provider's instructions and report any unusual symptoms promptly.

When taking this medication, some individuals may experience mild side effects such as nausea, headache, and diarrhea. These are common and often not serious; however, if they persist or worsen, it's advisable to consult a healthcare provider. Occasionally, users may also report vomiting and dizziness. These symptoms usually do not cause concern but should be monitored.

More serious side effects are rare but require immediate attention. These include persistent sore throat, a rapid or pounding heartbeat, tingling or numbness in the hands or feet, changes in vision, easy bruising or bleeding, and unusual tiredness. Additionally, the medication can lead to a severe intestinal condition due to C. difficile bacteria, which may manifest as persistent diarrhea, abdominal pain, or blood/mucus in the stool. It's important not to use anti-diarrhea or opioid products if these symptoms occur, as they may worsen the condition.

Prolonged use of the medication might result in oral thrush or a new yeast infection. Watch for signs such as white patches in the mouth or changes in vaginal discharge, and contact a healthcare provider if these appear. A severe allergic reaction is also possible, though rare. Symptoms may include rash, itching or swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. Immediate medical assistance is crucial if any of these occur. Always contact your healthcare provider if you notice any effects not listed.