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This document outlines essential safety information regarding the use of Sivextro (tedizolid). It is crucial to understand the associated risks and precautions to ensure safe use of this medication. If you have any questions or concerns, please consult your healthcare provider.

• Risk of C. difficile Infection: Sivextro (tedizolid) can alter the balance of bacteria in your gut, potentially leading to an overgrowth of Clostridioides difficile (C. diff). This can result in severe diarrhea. Symptoms of a C. diff infection to watch for include rapid heart rate, foul-smelling diarrhea, fever, nausea, and frequent bowel movements (up to 15 times per day). Seek immediate medical attention if you experience these symptoms to receive appropriate testing and treatment.

• Drug-Resistant Bacteria: It is essential to take Sivextro (tedizolid) exactly as prescribed. Deviating from the prescribed duration or using it for non-intended illnesses increases the risk of developing antibiotic-resistant infections. Such infections can be severe and may pose significant treatment challenges.

Please adhere to these guidelines to mitigate risks and ensure the effectiveness of your treatment. Always follow your healthcare provider's instructions and report any unusual symptoms promptly.

When taking Sivextro (tedizolid phosphate), it's important to be aware of potential interactions with other medications and certain foods. Sivextro can increase the levels of drugs that are substrates of the Breast Cancer Resistance Protein (BCRP) when taken orally. This means that medications like Methotrexate, topotecan, and Rosuvastatin may have higher concentrations in your body, potentially leading to increased side effects. If you're on any of these medications, your healthcare provider may consider adjusting your treatment or closely monitoring you for adverse reactions.

Additionally, Sivextro has the potential to interact with serotonergic agents, such as certain antidepressants (e.g., SSRIs, tricyclic antidepressants), migraine medications (e.g., triptans), and opioids like Meperidine. Combining these with Sivextro may increase the risk of serotonin syndrome, a rare but serious condition characterized by symptoms like confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, or muscle rigidity. While the occurrence is uncommon, it's essential to inform your healthcare provider about all the medications you're taking to assess any potential risks.

Regarding food interactions, Sivextro is a weak, reversible inhibitor of monoamine oxidase (MAO). This means that consuming foods high in tyramine—such as aged cheeses, smoked meats, and certain alcoholic beverages—while on Sivextro could potentially lead to increased blood pressure or other side effects. Although the risk is considered low, it's advisable to discuss your diet with your healthcare provider to ensure safety during treatment.

Always provide your healthcare provider with a complete list of all medications, supplements, and dietary habits to ensure the safe and effective use of Sivextro.