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The following highlights crucial safety information and warnings associated with the use of this medication. Carefully consider these details, and consult your healthcare provider for further guidance.

• Severe Muscle Pain and Damage: Rosuvastatin (Crestor) can rarely cause a serious muscle condition known as rhabdomyolysis, which may result in kidney damage. The risk increases if you are taking other medications that elevate rosuvastatin levels or also cause muscle issues. Discontinue use immediately and seek medical attention if you experience symptoms like intense muscle pain, tenderness, weakness, dark urine, or fatigue. Those at higher risk include individuals aged 65 and older, those of Asian descent, people with uncontrolled hypothyroidism, those with existing kidney issues, or those on higher doses of rosuvastatin.

• Liver Issues: Some users have noted changes in liver enzymes, which might indicate liver problems. While often temporary and symptomless, serious liver issues, including liver failure, have occurred. Consult your healthcare provider if you have a history of liver issues or consume large amounts of alcohol.

• Elevated Blood Sugar Levels: Statins, including rosuvastatin, may increase blood sugar, potentially affecting hemoglobin A1C levels. Although the benefits of statins generally outweigh this concern, inform your healthcare provider if you have diabetes or a history of high blood sugar. You may need to monitor your blood sugar levels more closely and maintain a healthy diet and regular exercise routine.

• Risks During Pregnancy or Breastfeeding: Rosuvastatin is generally not recommended for those who are pregnant or breastfeeding due to potential harm to the baby. Discuss safer alternatives with your healthcare team if you are pregnant, planning to become pregnant, or breastfeeding.

Contraindications: Avoid using this medication if you have severe liver problems, such as liver failure or cirrhosis, or if you are currently pregnant or breastfeeding, as it may pose serious health risks. Always discuss with your healthcare provider if these conditions apply to you.

Common side effects:

• Muscle pain
• Joint pain
• Headache
• Nausea
• Constipation

Less common but important to monitor:

• Stomach pain
• Dizziness
• Rash
• Itchy skin
• Hives
• Elevated blood sugar levels

Serious side effects:

• Rhabdomyolysis
• Severe muscle weakness or pain
• Fever
• Fatigue
• Liver problems or liver failure
• Swelling of the stomach
• Yellowing of the skin or eyes
• Confusion
• Dark urine
• Very serious allergic reaction
• Swelling of the face, tongue, or throat
• Difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Red yeast rice products

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Daptomycin
• Gemfibrozil
• Ledipasvir
• Sofosbuvir/Velpatasvir/Voxilaprevir
• Amprenavir
• Atazanavir
• Bezafibrate
• Capmatinib
• Ciprofibrate
• Cobicistat
• Colchicine
• Cyclosporine
• Darolutamide
• Darunavir
• Dasabuvir
• Elagolix
• Elbasvir
• Eluxadoline
• Enasidenib
• Eslicarbazepine Acetate
• Fenofibrate
• Fenofibric Acid
• Fosamprenavir
• Grazoprevir
• Indinavir
• Lasmiditan
• Ledipasvir
• Leflunomide
• Lopinavir
• Niacin
• Ombitasvir
• Paritaprevir
• Regorafenib
• Ritonavir
• Rolapitant
• Saquinavir
• Simeprevir
• Teriflunomide
• Velpatasvir
• Voxilaprevir
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Acenocoumarol
• Amiodarone
• Dicumarol
• Eltrombopag
• Fluconazole
• Fostemsavir
• Glecaprevir
• Itraconazole
• Oat Bran
• Pectin
• Phenprocoumon
• Pibrentasvir
• Tipranavir