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Celecoxib, a nonsteroidal anti-inflammatory drug, carries important safety warnings and potential risks that you should be aware of before use. Reviewing the following information with your healthcare provider is crucial, especially if you have pre-existing conditions or are taking other medications.

• Heart Risks: Celecoxib may increase the risk of heart attack or stroke, particularly if used long-term or if you have heart disease or risk factors such as smoking, high blood pressure, or diabetes. Avoid taking this medication immediately before or after heart bypass surgery. Seek emergency help if you experience symptoms like chest pain, difficulty breathing, or sudden weakness or speech trouble.

• Stomach and Intestinal Bleeding: There is a risk of serious and potentially fatal bleeding in the stomach or intestines, which can occur without warning. This risk is higher in older adults and those with a history of ulcers or bleeding disorders, especially if taking blood thinners or corticosteroids. Seek medical assistance if you notice persistent stomach pain, black or tarry stools, or vomit that resembles coffee grounds.

• Liver Concerns: Although rare, celecoxib can cause liver damage, which may lead to liver failure. Symptoms such as fatigue, nausea, jaundice, or dark urine should prompt immediate medical evaluation.

• Blood Pressure and Heart Failure: Celecoxib can elevate blood pressure and potentially lead to heart failure by causing fluid retention. Inform your healthcare provider if you have heart conditions or are on blood pressure medication.

• Kidney Function: The drug may impair kidney function, especially in patients with pre-existing kidney, liver, or heart issues, or those taking certain blood pressure medications. Notify your provider if you experience changes in urination.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, may occur, particularly in individuals with a sulfa drug allergy. Seek immediate care if you develop hives, swelling, or breathing difficulties.

• Asthma: Use caution if you have asthma, as celecoxib can worsen asthma symptoms or trigger severe attacks. Get urgent help if you experience airway constriction.

• Pregnancy Risks: Celecoxib should not be taken after the 20th week of pregnancy as it may harm the unborn baby, causing heart or kidney issues. Discuss alternative treatments with your healthcare provider if you are pregnant.

• Contraindications: Do not use celecoxib if you have a history of allergies to NSAIDs or sulfa drugs, or if you've recently undergone coronary artery bypass surgery.

Always ensure that your healthcare provider is informed of your complete medical history and current medications before starting celecoxib. In case of an overdose, contact emergency services immediately.

Common side effects:

• Headaches
• Indigestion
• Upper respiratory infections
• Diarrhea
• Sinus infections
• Belly pain
• Fever
• Nausea
• Cough
• Symptoms of a common cold

Less common but important to monitor:

• Passing gas
• Back pain
• Muscle or joint pain
• Dizziness
• Trouble sleeping
• Ringing in the ears
• Dry mouth
• Rash
• Swelling in the arms and legs
• Sore throat

Serious side effects:

• Signs of heart failure
• Symptoms of liver damage
• Severe allergic reactions
• Severe stomach pain
• Vomiting
• Unusual changes in urine output

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac.

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren, ACE inhibitors (such as Captopril, Lisinopril), angiotensin II receptor blockers (such as Valsartan, Losartan).
• Cidofovir.
• Lithium.
• Diuretics (such as Furosemide).
• Anti-platelet drugs (such as Clopidogrel), blood thinners (such as Dabigatran, Enoxaparin, Warfarin).

Interactions with low risk that usually do not require a change in therapy:

• Pain relievers/fever reducers (Aspirin, NSAIDs such as Naproxen or Ibuprofen).