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This safety information outlines the potential risks and precautions associated with using Brinzolamide (Azopt). It is essential to read these details carefully and consult your healthcare provider with any questions or concerns.

• Allergic Reactions: Brinzolamide (Azopt) is a sulfa-based medication, and even though it is applied to the eye, some may enter the bloodstream and potentially cause allergic reactions elsewhere in the body. Severe sulfa allergies can lead to serious conditions such as intense rashes, liver damage, or a decrease in blood cell count, which may be life-threatening. Mild allergic reactions might cause irritation to the eyes or eyelids. If you experience symptoms like a serious rash, abdominal pain, or general weakness, discontinue use immediately and consult your healthcare provider. If you have a history of sulfa allergies, such as reactions to medications like Bactrim or Septra, discuss alternatives with your provider.

• Cornea Swelling: This medication may lead to corneal swelling. If you have been informed that your cornea has a low cell count or is thinner than normal, consult your healthcare provider before beginning treatment with Brinzolamide (Azopt).

• Caution with Kidney Disease: Individuals with severe kidney disease should avoid using Brinzolamide (Azopt) as the medication is primarily eliminated by the kidneys. Impaired kidney function can lead to medication accumulation and increased risk of side effects. If you have kidney disease, speak with your healthcare provider prior to starting this medication.

• Not Suitable for Acute Angle-Closure Glaucoma: Brinzolamide (Azopt) is intended for treating open-angle glaucoma and is not recommended for acute angle-closure glaucoma, which requires immediate treatment to reduce eye pressure. Do not use this medication for acute angle-closure glaucoma unless specifically advised by your healthcare provider.

• Avoid Soft Contact Lenses: The preservative benzalkonium chloride in Brinzolamide (Azopt) can be absorbed by soft contact lenses, potentially causing damage. It is recommended to remove soft lenses before administering the medication and wait at least 15 minutes before reinserting them.

Common side effects:

• temporary blurred vision
• bitter or unusual taste in the mouth
• dry eyes
• sensation of something in the eye
• eye discomfort
• itching
• redness
• discharge
• headache

Less common but important to monitor:

• eyelid inflammation
• eye pain
• cornea inflammation
• runny nose

Serious side effects:

• persistent nausea or vomiting
• swelling or pain in the eye or eyelid
• stomach or back pain
• yellowing of the skin or eyes
• dark urine
• unexplained bruising or bleeding
• unusual tiredness
• signs of infection like a persistent sore throat, fever, or chills
• very serious allergic reaction (symptoms like rash, facial swelling, severe dizziness, or breathing difficulties)

When using brinzolamide eye drops, it's important to be aware of potential interactions with other medications:

• Oral Carbonic Anhydrase Inhibitors: Combining brinzolamide with oral carbonic anhydrase inhibitors (such as Acetazolamide) can intensify systemic side effects. Therefore, concurrent use is generally not recommended.

• High-Dose Salicylate Therapy: High doses of salicylates (like Aspirin) may lead to acid-base and electrolyte imbalances when used with carbonic anhydrase inhibitors. While such effects were not observed in clinical trials with brinzolamide, caution is advised if you're on high-dose salicylate therapy.

• Alpha-/Beta-Agonists (Indirect-Acting): Brinzolamide may increase the serum concentration of indirect-acting alpha-/beta-agonists, necessitating careful monitoring.

• Amantadine: The serum concentration of amantadine can be elevated when taken with brinzolamide, so monitoring is recommended.

• Other Carbonic Anhydrase Inhibitors: Using multiple carbonic anhydrase inhibitors together can enhance adverse effects. It's advisable to avoid such combinations and monitor for issues like kidney stones and metabolic acidosis if concurrent use is necessary.

• Strong CYP3A4 Inhibitors: Medications that strongly inhibit the CYP3A4 enzyme may increase brinzolamide levels in the body, requiring careful monitoring.

• Antifungal Medications: Antifungals like Itraconazole or Clotrimazole can interact with brinzolamide.

• Ritonavir: This antiviral medication may affect how brinzolamide works.

• Metformin: Used for diabetes, metformin can interact with brinzolamide.

Additionally, the combination of brinzolamide with Brimonidine (found in some eye drops) may interact with:

• Central Nervous System Depressants: Brimonidine can enhance the effects of CNS depressants, leading to increased drowsiness.

• Antihypertensives and Cardiac Glycosides: Brimonidine may lower blood pressure, so caution is advised when used with these medications.

• Tricyclic Antidepressants: These may reduce the effectiveness of brimonidine in lowering intraocular pressure.

• Monoamine Oxidase Inhibitors (MAOIs): Using brimonidine with MAOIs can lead to increased systemic side effects, such as hypotension.

Always inform your healthcare provider about all medications and supplements you're taking to ensure safe and effective use of brinzolamide.