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This safety information outlines the potential risks and precautions associated with using Brinzolamide (Azopt). It is essential to read these details carefully and consult your healthcare provider with any questions or concerns.

• Allergic Reactions: Brinzolamide (Azopt) is a sulfa-based medication, and even though it is applied to the eye, some may enter the bloodstream and potentially cause allergic reactions elsewhere in the body. Severe sulfa allergies can lead to serious conditions such as intense rashes, liver damage, or a decrease in blood cell count, which may be life-threatening. Mild allergic reactions might cause irritation to the eyes or eyelids. If you experience symptoms like a serious rash, abdominal pain, or general weakness, discontinue use immediately and consult your healthcare provider. If you have a history of sulfa allergies, such as reactions to medications like Bactrim or Septra, discuss alternatives with your provider.

• Cornea Swelling: This medication may lead to corneal swelling. If you have been informed that your cornea has a low cell count or is thinner than normal, consult your healthcare provider before beginning treatment with Brinzolamide (Azopt).

• Caution with Kidney Disease: Individuals with severe kidney disease should avoid using Brinzolamide (Azopt) as the medication is primarily eliminated by the kidneys. Impaired kidney function can lead to medication accumulation and increased risk of side effects. If you have kidney disease, speak with your healthcare provider prior to starting this medication.

• Not Suitable for Acute Angle-Closure Glaucoma: Brinzolamide (Azopt) is intended for treating open-angle glaucoma and is not recommended for acute angle-closure glaucoma, which requires immediate treatment to reduce eye pressure. Do not use this medication for acute angle-closure glaucoma unless specifically advised by your healthcare provider.

• Avoid Soft Contact Lenses: The preservative benzalkonium chloride in Brinzolamide (Azopt) can be absorbed by soft contact lenses, potentially causing damage. It is recommended to remove soft lenses before administering the medication and wait at least 15 minutes before reinserting them.

Common side effects:

• temporary blurred vision
• bitter or unusual taste in the mouth
• dry eyes
• sensation of something in the eye
• eye discomfort
• itching
• redness
• discharge

• headache

  Less common but important to monitor:

• eyelid inflammation
• eye pain
• cornea inflammation

• runny nose

  Serious side effects:

• persistent nausea or vomiting
• swelling or pain in the eye or eyelid
• stomach or back pain
• yellowing of the skin or eyes
• dark urine
• unexplained bruising or bleeding
• unusual tiredness
• signs of infection like a persistent sore throat, fever, or chills
• very serious allergic reaction (symptoms like rash, facial swelling, severe dizziness, or breathing difficulties)