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Antidepressant medications are prescribed to manage depression and various mental or mood disorders. They offer significant benefits, including the reduction of suicidal thoughts and behaviors. However, it is crucial to be aware that a small percentage of individuals, particularly those under the age of 25, may experience an increase in depression, mood alterations, or suicidal ideation when using these medications.

Key safety considerations include:

• Discuss the pros and cons of antidepressant use with a healthcare provider, especially for individuals under 25, regardless of whether the medication is intended for a mental health condition.
• Immediately inform a doctor if there are signs of worsening depression, any psychiatric symptom changes, or unusual behavior, such as suicidal thoughts, new or increased anxiety, panic attacks, sleep disturbances, irritability, aggressive behaviors, impulsiveness, severe restlessness, or rapid speech.
• Pay close attention to these symptoms when starting a new antidepressant or adjusting the dosage.

These precautions are vital to ensure the safe and effective use of antidepressant medications.

When taking this medication, you may experience some mild side effects such as nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, headache, muscle aches, dry mouth, a bad taste in the mouth, stuffy nose, constipation, or changes in weight and sexual interest/ability. These are generally manageable, but if they persist or worsen, consult your healthcare provider. To alleviate dry mouth, consider using sugarless candy, chewing gum, or drinking water. For dizziness, rise slowly from sitting or lying positions to reduce risk.

Be vigilant for any serious side effects, including tremors, nightmares, ringing in the ears, difficulty urinating, blood in urine, persistent sore throat or fever, shortness of breath, or abdominal pain, and inform your doctor immediately if they occur. Urgent medical attention is needed for very serious symptoms such as chest pain, fainting, irregular heartbeat, seizures, eye pain, or vision changes.

There is a rare risk of developing serotonin syndrome, especially if combined with other serotonin-boosting drugs. Seek immediate help if you experience fast heartbeats, hallucinations, loss of coordination, severe nausea or dizziness, muscle twitching, unexplained fever, or unusual agitation. In rare cases, males may experience a painful or prolonged erection lasting over 4 hours, requiring immediate medical intervention to prevent permanent damage.

Severe allergic reactions are uncommon but seek immediate medical care if you notice symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing. Always keep your healthcare provider informed about any new or unusual symptoms you experience.

The medication you are taking may have interactions with other drugs, such as Digoxin. It's crucial to avoid using MAO inhibitors—like isocarboxazid, Linezolid, and others listed—while on this medication, as combining them can lead to a severe, potentially life-threatening reaction. MAO inhibitors should not be used for two weeks before and after your treatment. Consult your doctor for guidance on when to begin or discontinue use.

Certain drugs can interfere with how your body processes trazodone, potentially altering its effectiveness. These include some antifungal medications (like Itraconazole, Ketoconazole), HIV treatments (such as indinavir), antibiotics (like Erythromycin), and seizure medications (such as Phenytoin).

There is an increased risk of serotonin syndrome, a serious condition, if you are also taking drugs that boost serotonin levels. Such drugs include certain street drugs (like MDMA/"ecstasy"), St. John's wort, and some antidepressants (SSRIs and SNRIs like Fluoxetine, paroxetine, Duloxetine, Venlafaxine). This risk may be heightened when starting or increasing the dosage of these medications.

Inform your doctor or pharmacist if you are also using other products that cause drowsiness, including alcohol, cannabis, antihistamines (like Cetirizine, diphenhydramine), sleep or anxiety medications (such as Alprazolam, Diazepam, Zolpidem), muscle relaxants, and opioid pain medications (like codeine).

Be sure to read the labels on all your medications, including those for allergies or cough and cold, as they may contain ingredients that cause drowsiness. Discuss with your pharmacist how to use these products safely.