Bupropion Hcl ER (xl) Coupons & Savings Card – Discount Prices from $12.02

When considering the use of bupropion hydrochloride extended-release (XL), it's important to be aware of several significant risks associated with this medication:

Seizure Risk: Bupropion XL can increase the likelihood of seizures, especially at higher doses. To minimize this risk, it's crucial to adhere to the prescribed dosage and avoid exceeding 300 mg once daily. Individuals with a history of seizure disorders, eating disorders like anorexia or bulimia, or those undergoing abrupt withdrawal from alcohol or sedatives should not use bupropion XL due to an elevated seizure risk.

Elevated Blood Pressure: Treatment with bupropion XL may lead to increased blood pressure and hypertension. It's advisable to monitor blood pressure before starting the medication and periodically during treatment. The risk of hypertension is heightened when bupropion XL is used alongside monoamine oxidase inhibitors (MAOIs) or other drugs that enhance dopaminergic or noradrenergic activity.

Neuropsychiatric Symptoms: Some individuals taking bupropion XL have reported mood changes, including depression and mania, as well as psychosis, hallucinations, paranoia, delusions, aggression, anxiety, and panic. These symptoms have occurred in patients with and without a history of psychiatric conditions. If such reactions occur, it's important to discontinue the medication and consult a healthcare provider promptly.

Activation of Mania/Hypomania: Antidepressant treatment, including bupropion XL, can trigger manic, mixed, or hypomanic episodes, particularly in individuals with bipolar disorder or those with risk factors for bipolar disorder. Before starting bupropion XL, screening for a history of bipolar disorder and related risk factors is recommended.

Angle-Closure Glaucoma: Bupropion XL may cause pupil dilation, which can precipitate an angle-closure attack in individuals with anatomically narrow angles who do not have a patent iridectomy. Those susceptible to angle-closure glaucoma should use this medication with caution.

Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, have been reported with bupropion use. Symptoms may include itching, hives, swelling, and difficulty breathing. If any signs of a severe allergic reaction occur, discontinue the medication and seek immediate medical attention.

Misuse and Abuse Potential: Bupropion XL tablets are intended for oral use only. Inhaling crushed tablets or injecting dissolved tablets has been reported to cause seizures and, in some cases, death. It's essential to use the medication strictly as prescribed.

Being informed about these risks can help ensure the safe use of bupropion XL. Always discuss any concerns or pre-existing conditions with your healthcare provider before starting this medication.

Bupropion hydrochloride extended-release (XL) is a medication commonly prescribed for depression and seasonal affective disorder. While many individuals tolerate it well, some may experience side effects. Common Side Effects: These side effects are generally mild and may diminish as your body adjusts to the medication:

• Dry Mouth: A sensation of dryness in the mouth.
• Nausea or Vomiting: Feeling sick to your stomach or actual vomiting.
• Constipation: Difficulty in bowel movements.
• Headache: Pain or discomfort in the head.
• Insomnia: Difficulty falling or staying asleep.
• Dizziness: Feeling lightheaded or unsteady.
• Sweating: Increased perspiration.
• Tremor: Involuntary shaking movements.
• Weight Loss: A decrease in body weight. Serious Side Effects: Although less common, some side effects require immediate medical attention:
• Seizures: Convulsions or fits.
• High Blood Pressure: Elevated blood pressure readings.
• Manic Episodes: Periods of abnormally elevated mood, energy, and activity levels.
• Unusual Thoughts or Behaviors: Experiencing hallucinations, delusions, or paranoia.
• Visual Problems: Eye pain, changes in vision, or swelling/redness around the eye. Allergic Reactions: Seek emergency medical help if you notice signs of a severe allergic reaction, such as:
• Rash or itching.
• Swelling, especially of the face, tongue, or throat.
• Severe dizziness.
• Difficulty breathing. Important Considerations: Bupropion may increase the risk of suicidal thoughts and behaviors, particularly in individuals under 25 years old. It's crucial to monitor for any changes in mood or behavior and report them to your healthcare provider promptly. If you experience any side effects that are severe, persistent, or concerning, contact your doctor immediately. They can provide guidance on managing side effects or adjusting your treatment plan if necessary.

When taking bupropion hydrochloride extended-release (XL), it's important to be aware of potential interactions with other substances:

Medications Affecting Bupropion Levels:

• CYP2B6 Inhibitors: Drugs like ticlopidine and Clopidogrel can increase bupropion levels in your body. This may necessitate a dosage adjustment of bupropion.

• CYP2B6 Inducers: Medications such as Ritonavir, lopinavir, and Efavirenz can decrease bupropion levels, potentially reducing its effectiveness. In such cases, a higher dose of bupropion might be required, but it should not exceed the recommended maximum.

Bupropion's Effect on Other Medications:

• CYP2D6 Substrates: Bupropion can inhibit the enzyme CYP2D6, leading to increased levels of certain drugs metabolized by this enzyme. These include some antidepressants (e.g., Venlafaxine, paroxetine), antipsychotics (e.g., Haloperidol, Risperidone), beta-blockers (e.g., metoprolol), and antiarrhythmics (e.g., Propafenone, Flecainide). Dosage adjustments of these medications may be necessary when taken with bupropion.

Medications Lowering Seizure Threshold:

Combining bupropion with other drugs that lower the seizure threshold, such as antipsychotics, other antidepressants, Theophylline, or systemic corticosteroids, can increase the risk of seizures. It's advisable to start with a low dose of bupropion and increase it gradually under medical supervision.

Dopaminergic Drugs:

Concurrent use of bupropion with medications like Levodopa or Amantadine, which affect dopamine levels, may lead to central nervous system toxicity. Symptoms can include restlessness, agitation, tremor, and dizziness. Caution is recommended when these drugs are used together.

Alcohol:

Drinking alcohol while on bupropion can lead to adverse neuropsychiatric events or reduced alcohol tolerance. It's best to minimize or avoid alcohol consumption during treatment.

Monoamine Oxidase Inhibitors (MAOIs):

Using MAOIs with bupropion is contraindicated due to the risk of hypertensive reactions. A gap of at least 14 days should be maintained between stopping an MAOI and starting bupropion, and vice versa.

Always inform your healthcare provider about all medications and supplements you're taking to ensure safe and effective use of bupropion.