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When taking antidepressant medications such as Auvelity (dextromethorphan/bupropion), it is essential to be aware of potential risks and necessary precautions. Below is a summary of important safety information and instructions for use:

• Suicidal Thoughts or Behavior: There is a heightened risk of suicidal thoughts or behavior, particularly in individuals under 25 years of age. Monitor for any new or worsening depression and suicidal ideation, especially during the initial months of treatment or following a dose adjustment. Contact your healthcare provider immediately if you experience unusual mood changes or thoughts of self-harm.

• Seizure Risk: The component bupropion in Auvelity can increase the risk of seizures, particularly if taken in higher-than-recommended doses. Do not use this medication if you have a history of seizures or conditions that elevate seizure risk, such as head trauma, eating disorders, or recent cessation of alcohol or specific medications (benzodiazepines, barbiturates, seizure medications). Consult your healthcare provider for guidance.

• High Blood Pressure: Bupropion may lead to increased blood pressure, especially if combined with other medications that can also elevate blood pressure, like nicotine replacements or MAOIs. It is advised not to use MAOIs within 14 days of taking Auvelity. Regularly monitor your blood pressure and report any significant increases to your healthcare provider.

• Mood or Behavioral Changes: Antidepressants like Auvelity can induce mania or hypomania, more so in individuals with a personal or family history of bipolar disorder. Seek immediate medical attention if you experience extreme mood swings, irritability, or racing thoughts.

• Serotonin Syndrome: This rare but serious condition can occur if Auvelity is taken with other medications that affect serotonin levels (e.g., other antidepressants, certain antinausea medications, triptans, or St. John's wort). Symptoms include a rapid heart rate, sweating, muscle stiffness, fever, and confusion. If these symptoms occur, seek medical help immediately.

• Pregnancy Concerns: Animal studies suggest potential harm to unborn babies when Auvelity is used during pregnancy. If you are pregnant or planning to become pregnant, discuss safer alternatives with your healthcare provider. Notify your provider if you become pregnant while taking this medication.

Contraindications:

• Do not use if you have a seizure disorder.
• Avoid if you have a current or past eating disorder, such as anorexia or bulimia.
• Refrain from use if you are abruptly stopping alcohol, benzodiazepines, barbiturates, or antiseizure medications.
• Avoid taking Auvelity if you are using a monoamine oxidase inhibitor (MAOI) or have used one in the past 14 days.

For any concerns or additional information, always consult your healthcare provider.

When taking this medication, some common side effects may occur. These include dizziness, nausea, headache, dry mouth, and increased sweating. These effects are generally mild, but if they persist or worsen, consider consulting a healthcare provider. Some individuals may also experience sexual problems, such as erectile dysfunction or decreased libido, as well as diarrhea, drowsiness, constipation, trouble sleeping, and a reduced appetite. These are typically manageable but should be monitored.

There are also reports of other side effects like anxiety, joint pain, fatigue, tingling sensations, and blurry vision. While these can be concerning, they are less common and usually not severe. However, if any of these symptoms become bothersome, it is advisable to contact a healthcare professional.

Serious side effects, although rare, require immediate medical attention. These include seizures, eye pain or vision changes, and symptoms of serotonin syndrome, such as agitation, confusion, and a fast heart rate. Additionally, manic episodes characterized by drastic mood changes and sleep disturbances, or suicidal thoughts, necessitate urgent care. An allergic reaction to this medication is rare but serious, so seek medical help if you experience symptoms like a rash, severe dizziness, or difficulty breathing.

Some drugs that can interact with this medication include Pimozide and Thioridazine. Additionally, combining this medication with MAO inhibitors can lead to a severe and potentially life-threatening reaction. It is crucial to avoid using MAO inhibitors, such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine, while on this medication. Most MAO inhibitors should not be taken for at least two weeks before and after using this medication. Consult your doctor to determine the appropriate timing for starting or stopping this medication.

This drug contains both dextromethorphan and bupropion, so you should not take any other medications containing these ingredients unless your doctor advises otherwise. Additionally, this medication might affect certain laboratory tests, such as those for Parkinson's disease brain scans or urine screenings for amphetamines, leading to incorrect results. Ensure that all healthcare providers and lab technicians are informed that you are using this medication.