Trilostane

Drug Details

Trilostane is a medication primarily used to treat Cushing's disease (hyperadrenocorticism) in dogs and, less commonly, in cats. It works by inhibiting an enzyme called 3β-hydroxysteroid dehydrogenase, which is essential for the production of cortisol and other steroids in the adrenal glands. By blocking this enzyme, trilostane reduces the excessive cortisol levels characteristic of Cushing's disease, helping to alleviate symptoms such as increased thirst and urination, excessive appetite, and hair loss. Administered orally, trilostane is typically given once or twice daily with food. While generally well-tolerated, potential side effects include lethargy, vomiting, diarrhea, and loss of appetite. In rare cases, more serious effects like adrenal insufficiency can occur, necessitating close monitoring by a veterinarian. Trilostane should not be used in animals that are pregnant, nursing, or intended for breeding, and caution is advised in pets with kidney or liver impairment. Regular follow-up appointments and laboratory tests are essential to ensure the medication's effectiveness and to adjust dosing as needed.