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The use of benazepril (Lotensin) involves several important safety considerations that must be carefully reviewed. Below are the critical warnings and contraindications associated with this medication:

• Pregnancy Risks: Benazepril can cause severe harm, including birth defects or even death, to an unborn baby. The risk is particularly high if the medication is used during the second or third trimester of pregnancy. It is crucial to avoid pregnancy while on this medication. Discuss reliable birth control options with your doctor, and if you are planning to become pregnant, are pregnant, or suspect you might be pregnant, contact your doctor immediately and discontinue use.

• Angioedema: There is a risk of angioedema, which involves swelling of the face, lips, tongue, throat, or other organs, potentially causing difficulty breathing or gastrointestinal symptoms such as nausea and vomiting. This risk is increased in Black individuals, older adults, and females. Seek medical attention right away if you experience these symptoms.

• Kidney Health: Although benazepril is typically beneficial for the kidneys, it can exacerbate existing kidney issues, particularly in individuals with renal artery stenosis or severe heart failure. Regular kidney function tests may be needed to monitor your health. Notify your healthcare provider if you notice decreased urination.

• High Potassium Levels: The medication can increase potassium levels, which may lead to heart problems. This risk is elevated in those with diabetes, existing kidney issues, or when taken with other potassium-raising drugs. Report symptoms like nausea, muscle weakness, or abnormal heart rhythms to your healthcare provider right away.

• Low Blood Pressure: Benazepril lowers blood pressure, which might cause dizziness or lightheadedness, especially in those with heart issues or dehydration. Exercise caution when changing positions, and contact your provider if you experience these symptoms.

• Liver Health: Rarely, ACE inhibitors like benazepril can cause liver problems or failure due to bile duct blockage. Your provider may periodically check your liver function. Report any signs of liver issues, such as fatigue, abdominal pain, or jaundice, to your healthcare provider immediately.

Contraindications: Do not use benazepril if you have a history of angioedema, are taking a neprilysin inhibitor like sacubitril, or if you have diabetes and are also taking aliskiren (Tekturna). Always consult your healthcare provider to ensure this medication is safe for your use.

Common side effects:

• headaches
• dizziness
• tiredness
• dry cough
• rash
• nausea
• muscle pain

Serious side effects:

• angioedema
• serious kidney issues
• serious liver problems
• high potassium levels
• severely low blood pressure

Interactions with high risk of serious adverse effects and should be avoided:

• Aliskiren
• Sacubitril

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Everolimus
• Sirolimus
• Lithium
• ARBs (Losartan, Valsartan)
• Birth control pills containing drospirenone
• Amiloride
• Azathioprine
• Azilsartan
• Azilsartan Medoxomil
• Candesartan Cilexetil
• Canrenoate
• Eplerenone
• Eprosartan
• Irbesartan
• Mercaptopurine
• Olmesartan Medoxomil
• Potassium
• Spironolactone
• Telmisartan
• Triamterene
• Trimethoprim

Interactions with low risk that usually do not require a change in therapy:

• NSAIDs (Ibuprofen, Naproxen)
• Bee or wasp sting allergy shots