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Tromethamine is used to treat metabolic acidosis, a condition where there is too much acid in the body fluids. It helps to restore the normal acid-base balance in the body.

Tromethamine can cause several side effects and potential dangers, particularly if not used correctly. Some of the risks include metabolic imbalances, such as metabolic alkalosis, and electrolyte disturbances. It may also cause respiratory issues, such as hyperventilation, and cardiovascular effects, including hypotension or arrhythmias. Allergic reactions, though rare, can occur. It is important for tromethamine to be administered under medical supervision to monitor for these potential adverse effects.

Tromethamine is used in vaccines as a buffering agent. It helps to maintain the pH stability of the vaccine, ensuring that the vaccine remains effective and safe for use. This stability is crucial for preserving the integrity of the vaccine's active ingredients during storage and administration.

Tromethamine can cause skin irritation as a side effect. This may include redness, itching, or a rash at the site of application or contact. If any severe reactions occur, it is important to seek medical attention.

Tromethamine is generally considered safe for use in skincare products. It is commonly used as a pH adjuster to help maintain the stability and effectiveness of the formulation. As with any ingredient, individuals with sensitive skin or allergies should perform a patch test before using a new product containing tromethamine. If any irritation or adverse reaction occurs, it is advisable to discontinue use and consult a healthcare professional.