Tromethamine

Drug Details

Tromethamine, also known as THAM, is a medication used to prevent and correct metabolic acidosis—a condition where the body's fluids become too acidic. It works by binding to hydrogen ions, which helps neutralize excess acid in the blood. This action is particularly beneficial during or after cardiac bypass surgery and in cases of cardiac arrest, where acidosis can be a significant concern. Additionally, tromethamine acts as an osmotic diuretic, increasing urine flow and aiding in the removal of acids and electrolytes from the body. The drug is primarily eliminated through the kidneys, with most of it appearing in the urine within eight hours after administration.