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Enalapril (Vasotec) is a medication that requires careful consideration due to its associated risks and necessary precautions. Below are the vital safety warnings and instructions for patients and healthcare providers:

• Pregnancy Warning: Enalapril (Vasotec) can cause severe, potentially life-threatening harm to an unborn baby. It should not be used during pregnancy. If you are pregnant, planning to become pregnant, or discover you are pregnant while on this medication, inform your healthcare provider immediately to explore alternative treatments for managing blood pressure.

• Risk of Angioedema: This medication can trigger angioedema, a serious condition characterized by swelling of the face, throat, and tongue, which can obstruct breathing. This risk is higher for Black individuals, older adults, or females. Immediate medical attention is necessary if you experience symptoms of swelling, stomach pain, or breathing difficulties. Treatment with enalapril must be discontinued if angioedema occurs.

• Low Blood Pressure Concerns: Enalapril may cause a significant drop in blood pressure, leading to dizziness, fatigue, or lightheadedness, especially when starting the medication or adjusting the dose. Stay well-hydrated and contact your healthcare provider if these symptoms occur. Seek urgent medical help if you experience a fall or head injury due to dizziness.

• Kidney Function Monitoring: Although beneficial for the kidneys, enalapril can potentially worsen existing kidney problems, particularly in individuals with conditions like renal artery stenosis or severe heart failure. Regular kidney function tests are recommended. If you notice reduced urination, inform your healthcare provider promptly.

• High Potassium Levels: Enalapril can increase potassium levels, which poses a risk of heart issues. Those with diabetes, kidney problems, or on medications that raise potassium should be cautious. Report symptoms such as nausea, muscle weakness, or irregular heartbeat to your healthcare provider immediately.

• Liver Health Alert: Rarely, enalapril may cause liver problems or failure. Liver function should be monitored through blood tests. Inform your healthcare provider if you experience symptoms like fatigue, stomach pain, or jaundice.

Contraindications: Enalapril should not be used in individuals with a history of angioedema, those taking aliskiren (Tekturna) with high blood sugar, or within 36 hours of neprilysin inhibitors like Entresto (sacubitril/valsartan). Consult your healthcare provider if any of these conditions apply to you before starting enalapril.

Enalapril, also known as Vasotec, can interact with various medications and supplements. It is crucial to inform your healthcare provider about all drugs and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications should not be taken with enalapril due to potential interactions. These include Aliskiren and sacubitril, which may require your doctor to avoid prescribing enalapril or adjust your other medications.

There are drugs that are generally not recommended to be used with enalapril unless absolutely necessary. If both are prescribed together, your doctor might alter the dosage or frequency. These medications include Everolimus, Sirolimus, Lithium, and drugs that may increase potassium levels such as Losartan, Valsartan, and Spironolactone.

Using enalapril with some other medications can heighten the risk of side effects, yet might be necessary for optimal treatment. Your doctor might adjust your treatment plan accordingly. These include non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Naproxen, and others such as Aspirin and Bumetanide.

It is also important to avoid enalapril if you are undergoing desensitization for bee or wasp stings, as this combination can lead to severe reactions. Always ensure your healthcare providers are aware of all medications you are taking to manage these interactions safely.