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The use of Zelnorm (tegaserod) comes with important safety information and warnings. It is crucial that you understand the potential risks and consult your healthcare provider if you have any concerns. Below are key safety points to consider:

• Heart Attacks and Strokes: Zelnorm may increase your risk of serious heart problems, including strokes and heart attacks. Do not use this medication if you have a history of stroke, heart attack, or chest pain. Be particularly cautious if you smoke, have high blood pressure, high cholesterol, diabetes, obesity, or are over 55 years old. Discuss any concerns with your healthcare provider.

• Intestinal Swelling and Injury (Ischemic Colitis): This medication can decrease blood flow to the intestines, leading to swelling and injury, potentially requiring hospitalization. If you have a history of heart disease, high blood pressure, high cholesterol, previous abdominal surgery, or are older than 60, your risk is elevated. Seek immediate medical attention if you experience rectal bleeding, bloody diarrhea, or new or worsening abdominal pain.

• Loss of Body Fluids from Diarrhea: By facilitating bowel movements, Zelnorm can cause severe diarrhea, leading to significant fluid loss. This may result in faintness, dizziness, or fainting, potentially necessitating hospitalization for rehydration. Discontinue use and contact your provider if these symptoms occur.

• Suicidal Thoughts and Behavior: There is an increased risk of suicidal thoughts and behaviors, particularly when taken with antidepressants or if you have a history of such issues. These symptoms are more likely during the initial treatment period. If you or others notice worsening depression or the emergence of suicidal thoughts, stop taking the medication and seek immediate medical help.

Contraindications: Zelnorm should not be used if you have any of the following conditions due to the potential for serious health risks:

• History of heart problems, such as stroke or heart attack.
• History of ischemic colitis (intestinal injury and swelling due to reduced blood flow).
• Severe kidney issues.
• Moderate to severe liver conditions.
• History of bowel blockage.

Always consult your healthcare provider before starting this medication to ensure it is safe for you based on your health history and current conditions.

When taking this medication, some common side effects may include headache, stomach or abdominal pain, nausea, gas, dizziness, and diarrhea. These effects are generally mild, but if they persist or worsen, it is advisable to consult a healthcare provider. Diarrhea is particularly common in the first week of treatment and usually improves over time. However, persistent diarrhea can lead to dehydration, so be alert for symptoms such as reduced urination, dry mouth, increased thirst, rapid heartbeat, or dizziness, and seek medical advice if these occur.

There are also other reported side effects such as low red blood cell count, increased appetite, tendon swelling, migraines, rectal bleeding, weakness, and joint problems. If you experience any of these, especially if severe, it is important to contact your healthcare provider.

Rare but serious side effects include intestinal damage due to reduced blood flow (ischemic colitis), characterized by symptoms like new or worsening abdominal pain, rectal bleeding, or bloody stools. Stop taking the medication and seek immediate medical attention if these symptoms appear. Additionally, the medication may increase the risk of suicidal thoughts and behaviors; notify a healthcare professional promptly if you notice mood changes, depression, or any thoughts of self-harm.

Very serious side effects, requiring urgent medical assistance, include signs of a heart attack such as chest or jaw pain, shortness of breath, and unusual sweating; signs of a stroke such as sudden numbness, confusion, or vision changes; and symptoms of a severe allergic reaction like rash, swelling, severe dizziness, or difficulty breathing. Always be vigilant for these symptoms and seek immediate medical help if they occur.