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When taking dicyclomine, it is important to be aware of specific safety considerations and potential risks. Please review the following information carefully and consult your healthcare provider if you have any concerns or experience any of the listed symptoms.

• Heart Rate Concerns: Dicyclomine may increase your heart rate, which can be problematic for individuals with heart conditions such as heart failure, previous heart attacks, or high blood pressure. Inform your healthcare team if you have any of these conditions and if you notice an increased heart rate or experience palpitations.

• Mental and Mood Changes: This medication can lead to alterations in mood and cognitive functions, such as confusion, memory loss, hallucinations, or euphoria. These symptoms typically resolve within 12 to 24 hours after discontinuation. Notify a healthcare professional immediately if you experience these changes, especially if you are aged 65 or older or have a history of mental health issues.

• Autonomic Function Alterations: Dicyclomine can affect involuntary bodily functions, potentially resulting in constipation, dry mouth, or changes in heartbeat and vision. These effects are more likely in individuals aged 65 or older.

• Muscle Weakness: In rare cases, dicyclomine can cause significant muscle weakness or paralysis, particularly if taken in doses higher than prescribed. Those with myasthenia gravis should avoid this medication unless deemed safe by a healthcare provider. Seek medical attention if you experience muscle weakness or difficulty moving.

• Gastrointestinal Caution: If you have undergone procedures like a colostomy and experience diarrhea, consult your healthcare provider before taking dicyclomine, as it may indicate a bowel obstruction.

• Urinary Issues: Individuals with prostate problems should use dicyclomine cautiously, as it may exacerbate these issues and lead to urination difficulties. Notify your healthcare provider if you experience worsening symptoms.

Contraindications indicate when dicyclomine should not be used due to potential serious health risks. Avoid this medication if you have:

• Myasthenia gravis
• Glaucoma
• Urinary tract blockage
• Gastrointestinal blockage
• Severe ulcerative colitis
• Reflux esophagitis
• Unstable bleeding conditions
• Are breastfeeding

Always consult your healthcare provider to ensure this medication is safe for you, especially if any of these conditions apply.

Common side effects:

• Dizziness
• Dry mouth
• Blurred vision
• Nausea

Less common but important to monitor:

• Sleepiness
• Weakness
• Nervousness

Serious side effects:

• Severe changes in mood or behavior
• Psychosis
• Hallucinations
• Confusion
• Extreme happiness
• Irregular heartbeat
• Fainting
• Chest discomfort
• Shortness of breath
• Fatigue

When taking dicyclomine, it's important to be aware of potential interactions with other medications and substances, as these can affect its effectiveness or increase the risk of side effects. Here are some key interactions to consider:

Other Anticholinergic Medications: Dicyclomine has anticholinergic properties, meaning it blocks certain nerve impulses. Combining it with other anticholinergic drugs can amplify side effects like dry mouth, constipation, blurred vision, and difficulty urinating. Such medications include:

• Antihistamines: Commonly used for allergies, such as diphenhydramine.

• Medications for Overactive Bladder: Including oxybutynin and Tolterodine.

• Certain Antidepressants: Like Amitriptyline.

• Medications for Parkinson's Disease: Such as Benztropine.

Medications Affecting Gastrointestinal Motility: Dicyclomine slows down gut movement. Taking it with other drugs that have similar effects can lead to excessive slowing of the digestive system. Examples include:

• Opioid Pain Relievers: Such as hydrocodone-acetaminophen combinations.

• Certain Antidiarrheal Medications: Like Loperamide.

Medications for Glaucoma: Dicyclomine can increase intraocular pressure, potentially worsening glaucoma. If you're using medications to manage this eye condition, consult your healthcare provider before starting dicyclomine.

Antacids: These are used to neutralize stomach acid and can interfere with the absorption of dicyclomine, reducing its effectiveness. It's advisable to take dicyclomine at least one hour before or two hours after taking antacids.

Alcohol: While there are no known direct interactions between dicyclomine and alcohol, consuming alcohol can enhance side effects like dizziness, drowsiness, and blurred vision. It's best to avoid or limit alcohol intake while on this medication.

Other Considerations: Dicyclomine may affect the absorption of certain medications, such as:

• Levodopa: Used for Parkinson's disease.

• Ketoconazole and Itraconazole: Antifungal medications.

• Slow-Dissolving Forms of Digoxin: Used for heart conditions.

To minimize potential interactions, always inform your healthcare provider about all prescription and over-the-counter medications, supplements, and herbal products you are currently taking before starting dicyclomine.