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This safety information outlines key risks and precautions associated with the use of Lubiprostone (Amitiza). It is crucial to follow these guidelines for safe usage and consult your healthcare provider if you have any concerns.

• Low Blood Pressure and Fainting: Lubiprostone can lead to low blood pressure shortly after administration, sometimes resulting in fainting or falls. This risk increases with the higher dose (24 mcg) or concurrent use of other blood pressure-lowering medications. Notify your healthcare provider if you experience vomiting or diarrhea, as these can also contribute to low blood pressure and fainting. Should you feel lightheaded or at risk of fainting, sit or lie down immediately and avoid sudden movements. Consult your provider to determine if continuing Lubiprostone is advisable.

• Breathing Difficulties: Some individuals may encounter chest tightness and breathing difficulties within 30 to 60 minutes after the initial dose. While these symptoms usually subside within a few hours, contact your healthcare provider to assess the safety of continuing treatment, as these respiratory effects may recur with subsequent doses.

• Intestinal Blockage: Lubiprostone should not be used if you have an intestinal or stomach blockage. Your healthcare provider will check for any signs of blockage before initiating treatment. Report any symptoms like abdominal pain, excessive fullness, or difficulty with gas or stool passage to your provider while on this medication.

Always adhere to your healthcare provider's recommendations and report any unusual symptoms or concerns promptly.

Common side effects:

• nausea
• diarrhea
• gas
• vomiting
• dry mouth
• runny nose
• cough
• headache
• joint or back pain
• trouble sleeping

Less common but important to monitor:

• breathing difficulties
• chest tightness

Serious side effects:

• swelling of the arms or legs
• mental or mood changes
• severe diarrhea or vomiting
• dizziness
• fainting
• trouble breathing
• chest pain
• serious allergic reaction (rash, itching, swelling, severe dizziness)

When taking lubiprostone, it's important to be aware of potential interactions with other medications:

• Methadone: This opioid may reduce the effectiveness of lubiprostone in treating constipation.

• Antidiarrheal Medications: Drugs like Alosetron and crofelemer, which slow down bowel movements, can counteract lubiprostone's effects.

• Anticholinergic Drugs: Medications such as Solifenacin, used for overactive bladder, may promote constipation and could diminish lubiprostone's benefits.

• Diuretics: Loop diuretics like Furosemide can increase the risk of low potassium levels, especially when combined with lubiprostone.

Always inform your healthcare provider about all medications, supplements, and herbal products you're taking to ensure safe and effective use of lubiprostone.