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When using this medication to treat hepatitis C, it is crucial to be aware of potential risks and necessary precautions to ensure safe and effective use. Below are important safety considerations:

• Liver Health Monitoring: While this medication is effective for hepatitis C, it may occasionally lead to serious liver issues or exacerbate existing liver conditions, including hepatitis B. Inform your healthcare provider if you have a history of hepatitis B or any liver disease. If you experience symptoms such as persistent nausea or vomiting, loss of appetite, abdominal pain, dark urine, or yellowing of the skin or eyes, contact your doctor immediately.

• Hepatitis B Reactivation: Individuals with a history of both hepatitis B and C might experience a reactivation of hepatitis B after starting treatment. This can lead to significant liver complications if not promptly addressed. It is essential to undergo hepatitis B testing before beginning treatment with Zepatier (elbasvir / grazoprevir) and notify your healthcare provider if you have had hepatitis B or received treatment for it previously.

• Monitoring Liver Tests: Clinical studies have shown that a small percentage of patients may experience elevated liver enzymes after starting Zepatier (elbasvir / grazoprevir). Regular liver function tests will be conducted by your healthcare provider to monitor your condition. Should your liver enzyme levels rise significantly, discontinuation of the medication may be necessary. Report any signs of jaundice, stomach pain, lack of appetite, nausea, vomiting, or fatigue to your provider without delay.

• Ribavirin Use: For certain liver conditions, ribavirin may be prescribed alongside Zepatier (elbasvir / grazoprevir). Ribavirin has numerous side effects and is contraindicated during pregnancy. Discuss the use of ribavirin with your healthcare provider and pharmacist to understand its risks and benefits.

• Drug Interactions: Zepatier (elbasvir / grazoprevir) can interact with other medications, potentially diminishing its efficacy or increasing side effects. Additionally, some substances may decrease Zepatier levels, affecting treatment outcomes. Ensure your healthcare team is aware of all medications and supplements you are taking, as adjustments may be required.

In case of an overdose or any adverse reactions, seek emergency medical attention promptly. Always consult your healthcare provider for personalized advice and before making any changes to your treatment regimen.

When using this medication, some common side effects may include tiredness, headache, and nausea. These effects are generally mild, but if they persist or worsen, it is advisable to consult a healthcare provider. In some rare instances, individuals may experience more serious allergic reactions. Symptoms of such reactions include rash, itching, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. Immediate medical attention is crucial if these symptoms occur.

Additionally, there are reports of other side effects like liver issues, which manifest as right upper abdominal pain, loss of appetite, nausea, light-colored stools, dark urine, yellowing of the skin or eyes, and unusual fatigue. These symptoms warrant prompt consultation with a healthcare professional.

There are also serious side effects that, although rare, require urgent medical care. These include significant diarrhea, severe fatigue, intense headache, pronounced nausea, and trouble sleeping. It is important to seek medical help if any of these severe symptoms are experienced. Always communicate with a healthcare provider regarding any side effects, especially if they are severe or concerning.